公开(公告)号：US20130140176A1

公开(公告)日：2013-06-06

申请号：US13756903

申请日：2013-02-01

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Terry Beaty ,  Henning Groll ,  Harvey Buck ,  Eric Diebold ,  Abner Joseph ,  Randy Riggles

IPC: G01N27/327

CPC classification number: G01N27/327 ,  G01N27/3272

Abstract: The present invention relates to a biosensor. The biosensor includes a support substrate, electrodes positioned on the support substrate, a spacer substrate positioned on the support substrate, and a cover positioned on the spacer substrate. The cover cooperates with the support substrate to define a capillary channel. The electrodes include at least one working electrode defining a working electrode area in the capillary channel. The working electrode is configured to minimize variation in the working electrode area in the capillary channel due to variations in the spacer substrate placement relative to the working electrode.

Abstract translation: 本发明涉及生物传感器。 生物传感器包括支撑基板，位于支撑基板上的电极，位于支撑基板上的间隔基板和位于间隔基板上的盖。 盖与支撑基板配合以限定毛细通道。 电极包括限定毛细通道中的工作电极区域的至少一个工作电极。 工作电极被配置为使得由于间隔基板相对于工作电极的位置的变化而使毛细通道中的工作电极面积的变化最小化。

公开(公告)号：US08685229B2

公开(公告)日：2014-04-01

申请号：US13938791

申请日：2013-07-10

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Henning Groll

IPC: G01N27/327

CPC classification number: B29C65/74 ,  G01N27/3272 ,  G01N33/48771

Abstract: The present invention provides a system of biosensors whose dose-response curves are maintained within a predetermined and desired range or tolerance during production by selecting a feature of the biosensors that can be varied during production. For example, in one exemplary embodiment the effective area of the working electrode of an electrochemical biosensor can be varied during production as needed to offset variations that occur, e.g., in the reagent of the biosensors as production proceeds. In another exemplary embodiment, the dose-response curve of biosensors not yet produced can be predicted and one or more features of these biosensors can be selected to maintain the dose-response curve within a predetermined range or tolerance.

Abstract translation: 本发明提供一种生物传感器系统，其生物传感器的剂量 - 反应曲线在生产过程中通过选择可在生产过程中变化的生物传感器的特征而保持在预定和期望的范围或公差范围内。 例如，在一个示例性实施例中，电化学生物传感器的工作电极的有效面积可以根据需要在生产过程中变化，以抵消例如当生产进行时在生物传感器的试剂中发生的变化。 在另一个示例性实施方案中，可以预测尚未产生的生物传感器的剂量 - 反应曲线，并且可以选择这些生物传感器的一个或多个特征，以将剂量 - 反应曲线保持在预定范围或公差范围内。

公开(公告)号：US20140318991A1

公开(公告)日：2014-10-30

申请号：US14330610

申请日：2014-07-14

Applicant: Roche Diagnostics Operations, Inc. ,  Roche Operations Ltd.

Inventor： Michael J. Celentano ,  Henning Groll ,  James L. Pauley ,  Steven K. Moore

IPC: G01N27/327

CPC classification number: G01N27/327 ,  G01N27/3273 ,  G01N27/3274 ,  G01N27/4163

Abstract: The present invention provides a test strip for measuring a signal of interest in a biological fluid when the test strip is mated to an appropriate test meter, wherein the test strip and the test meter include structures to verify the integrity of the test strip traces, to measure the parasitic resistance of the test strip traces, and to provide compensation in the voltage applied to the test strip to account for parasitic resistive losses in the test strip traces.

Abstract translation: 本发明提供了一种测试条，用于在将测试条配合到适当的测试仪器时测量生物流体中感兴趣的信号，其中测试条和测试仪包括用于验证测试条迹线的完整性的结构， 测量测试条迹线的寄生电阻，并对施加到测试条上的电压进行补偿，以考虑测试条迹线中的寄生电阻损耗。

公开(公告)号：US20140027279A1

公开(公告)日：2014-01-30

申请号：US13748932

申请日：2013-01-24

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Michael J. Celentano ,  Henning Groll ,  James L. Pauley ,  Steven K. Moore

IPC: G01N27/416

CPC classification number: G01N27/327 ,  G01N27/3273 ,  G01N27/3274 ,  G01N27/4163

Abstract: The present invention provides a test strip for measuring a signal of interest in a biological fluid when the test strip is mated to an appropriate test meter, wherein the test strip and the test meter include structures to verify the integrity of the test strip traces, to measure the parasitic resistance of the test strip traces, and to provide compensation in the voltage applied to the test strip to account for parasitic resistive losses in the test strip traces.

Abstract translation: 本发明提供了一种测试条，用于在将测试条配合到适当的测试仪器时测量生物流体中感兴趣的信号，其中测试条和测试仪包括用于验证测试条迹线的完整性的结构， 测量测试条迹线的寄生电阻，并对施加到测试条上的电压进行补偿，以考虑测试条迹线中的寄生电阻损耗。

公开(公告)号：US20130292033A1

公开(公告)日：2013-11-07

申请号：US13938791

申请日：2013-07-10

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Henning Groll

IPC: B29C65/74

CPC classification number: B29C65/74 ,  G01N27/3272 ,  G01N33/48771

Abstract: The present invention provides a system of biosensors whose dose-response curves are maintained within a predetermined and desired range or tolerance during production by selecting a feature of the biosensors that can be varied during production. For example, in one exemplary embodiment the effective area of the working electrode of an electrochemical biosensor can be varied during production as needed to offset variations that occur, e.g., in the reagent of the biosensors as production proceeds. In another exemplary embodiment, the dose-response curve of biosensors not yet produced can be predicted and one or more features of these biosensors can be selected to maintain the dose-response curve within a predetermined range or tolerance.

Abstract translation: 本发明提供一种生物传感器系统，其生物传感器的剂量 - 反应曲线在生产过程中通过选择可在生产过程中变化的生物传感器的特征而保持在预定和期望的范围或公差范围内。 例如，在一个示例性实施例中，电化学生物传感器的工作电极的有效面积可以根据需要在生产过程中变化，以抵消例如当生产进行时在生物传感器的试剂中发生的变化。 在另一个示例性实施方案中，可以预测尚未产生的生物传感器的剂量 - 反应曲线，并且可以选择这些生物传感器的一个或多个特征，以将剂量 - 反应曲线保持在预定范围或公差范围内。