公开(公告)号：US09945787B2

公开(公告)日：2018-04-17

申请号：US13737523

申请日：2013-01-09

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Rik Harbers ,  Kurt Schildknecht

IPC: G01N21/00 ,  G01N21/75 ,  G01J3/28 ,  G01J3/42 ,  G01N21/25

CPC classification number: G01N21/75 ,  G01J3/28 ,  G01J3/42 ,  G01N21/255

Abstract: An optical device for determining the presence and/or concentration of analytes in a sample is presented. The optical device comprises a detector and a detection unit comprising optical path components. The detection unit has wavelength-dependent responsivity. The optical device further comprises a light source for emitting light of different respective usable wavelength ranges. The light is guidable through the optical path to the detector to generate baseline signals and response signals relative to the baseline signal indicative of the presence and/or concentration of analytes in the optical path. The intensity of the light reaching the detector is adjusted inverse to the wavelength-dependent responsivity with respect to at least two respective usable wavelength ranges so that a reduction of the ratio between the maximum baseline signal at one of the selected usable wavelength ranges and the minimum baseline signal at another of the selected usable wavelength ranges is obtained.

公开(公告)号：US20130130400A1

公开(公告)日：2013-05-23

申请号：US13737523

申请日：2013-01-09

Applicant: ROCHE DIAGNOSTICS OPERATIONS, INC.

Inventor： Rik Harbers ,  Kurt Schildknecht

IPC: G01N21/75

CPC classification number: G01N21/75 ,  G01J3/28 ,  G01J3/42 ,  G01N21/255

Abstract: An optical device for determining the presence and/or concentration of analytes in a sample is presented. The optical device comprises a detector and a detection unit comprising optical path components. The detection unit has wavelength-dependent responsivity. The optical device further comprises a light source for emitting light of different respective usable wavelength ranges. The light is guidable through the optical path to the detector to generate baseline signals and response signals relative to the baseline signal indicative of the presence and/or concentration of analytes in the optical path. The intensity of the light reaching the detector is adjusted inverse to the wavelength-dependent responsivity with respect to at least two respective usable wavelength ranges so that a reduction of the ratio between the maximum baseline signal at one of the selected usable wavelength ranges and the minimum baseline signal at another of the selected usable wavelength ranges is obtained.

Abstract translation: 提出了用于确定样品中分析物的存在和/或浓度的光学装置。 光学装置包括检测器和包括光路部件的检测单元。 检测单元具有波长依赖的响应性。 光学装置还包括用于发射不同的各个可用波长范围的光的光源。 光通过到检测器的光路是可引导的，以相对于指示光路中分析物的存在和/或浓度的基线信号产生基线信号和响应信号。 到达检测器的光的强度相对于至少两个相应的可用波长范围与波长相关的响应度相反地调整，使得在所选择的可用波长范围之一的最大基线信号与最小基准信号之间的比率的减小 获得在所选择的可用波长范围中的另一个的基线信号。

公开(公告)号：US11112365B2

公开(公告)日：2021-09-07

申请号：US15909295

申请日：2018-03-01

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Rik Harbers ,  Kurt Schildknecht

IPC: G01N21/75 ,  G01J3/28 ,  G01J3/42 ,  G01N21/25

Abstract: An optical device for determining the presence and/or concentration of analytes in a sample is presented. The optical device comprises a detector and a detection unit comprising optical path components. The detection unit has wavelength-dependent responsivity. The optical device further comprises a light source for emitting light of different respective usable wavelength ranges. The light is guidable through the optical path to the detector to generate baseline signals and response signals relative to the baseline signal indicative of the presence and/or concentration of analytes in the optical path. The intensity of the light reaching the detector is adjusted inverse to the wavelength-dependent responsivity with respect to at least two respective usable wavelength ranges so that a reduction of the ratio between the maximum baseline signal at one of the selected usable wavelength ranges and the minimum baseline signal at another of the selected usable wavelength ranges is obtained.

公开(公告)号：US20180252651A1

公开(公告)日：2018-09-06

申请号：US15909295

申请日：2018-03-01

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Rik Harbers ,  Kurt Schildknecht

IPC: G01N21/75 ,  G01J3/28 ,  G01J3/42 ,  G01N21/25

CPC classification number: G01N21/75 ,  G01J3/28 ,  G01J3/42 ,  G01N21/255

Abstract: An optical device for determining the presence and/or concentration of analytes in a sample is presented. The optical device comprises a detector and a detection unit comprising optical path components. The detection unit has wavelength-dependent responsivity. The optical device further comprises a light source for emitting light of different respective usable wavelength ranges. The light is guidable through the optical path to the detector to generate baseline signals and response signals relative to the baseline signal indicative of the presence and/or concentration of analytes in the optical path. The intensity of the light reaching the detector is adjusted inverse to the wavelength-dependent responsivity with respect to at least two respective usable wavelength ranges so that a reduction of the ratio between the maximum baseline signal at one of the selected usable wavelength ranges and the minimum baseline signal at another of the selected usable wavelength ranges is obtained.