公开(公告)号：US20240352110A1

公开(公告)日：2024-10-24

申请号：US18745539

申请日：2024-06-17

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Alexander Jethwa ,  Tobias Oelschlaegel ,  Corinna Schindler ,  Monika Soukupova ,  Laura Stoeckl ,  Christina Zimmermann

IPC: C07K16/18 ,  G01N33/543 ,  G01N33/68

CPC classification number: C07K16/18 ,  G01N33/543 ,  G01N33/6896 ,  C07K2317/565 ,  G01N2333/4709 ,  G01N2470/04

Abstract: The present invention relates to a monoclonal antibody or an antigen-binding fragment thereof specifically binding to Aβ42 with advantageous features for Aβ42 detection in vitro using immunoassays. Also provided is a polynucleotide or a set of polynucleotides encoding the same and a vector comprising said polynucleotide(s). Further provided is a host cell comprising the polynucleotide(s) and a corresponding production process using this host cell. Also provided herein are uses and methods employing the monoclonal antibody or an antigen-binding fragment thereof specifically binding to Aβ42 as provided herein.