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公开(公告)号：US11267827B2
公开(公告)日：2022-03-08
申请号：US16284346
申请日：2019-02-25
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Hans-Peter Josel , Tobias Oelschlaegel , Giuseppe Prencipe , Luisa De Cola , Elena Longhi , Chien-Wei Hsu
Abstract: The present disclosure relates to novel multifunctionalized silicon nanoparticles, to processes for their preparation and to compositions comprising the novel multifunctionalized silicon nanoparticles. The disclosure also relates to the use of the novel multifunctionalized silicon nanoparticles in electrochemiluminescence based detection methods and in the in vitro detection of an analyte. In particular, the disclosure relates to methods for measuring an analyte by in vitro methods employing the novel multifunctionalized silicon nanoparticles.
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公开(公告)号：US11236386B2
公开(公告)日：2022-02-01
申请号：US16598685
申请日：2019-10-10
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Frank Bergmann , Tobias Oelschlaegel , Sebastian Johannes Pomplun
IPC: C12Q1/6869 , C07D295/13 , C07D487/04 , C07H21/02 , C07H21/04 , A61K47/68
Abstract: The present description relates to a method for binding to a target molecule having an aldehyde compound derived from N-(2-aminoethyl)pyrrole, which compound also has a moiety of interest, to compounds (conjugates) obtained by this method, having both the target molecule and the moiety of interest and to novel substances derived from N-(2-aminoethyl)pyrrole. In one embodiment, the compound has the formula of Formula II wherein R1, R2 and R3 independently are H, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl, wherein R4, R5, R6, R7 and R8 independently are H, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, or -LM, wherein L is absent or is a linker and M is a moiety of interest selected from a nucleotide, an oligonucleotide, a peptide, a label, a cytotoxic agent, a partner of a binding pair and a functional group, wherein two of R4, R5, R6, R7, and R8 optionally are linked to form a substituted or unsubstituted cycloalkyl or a substituted or unsubstituted heterocycloalkyl, and T is a target molecule selected from the group consisting of a solid phase, a polypeptide, a protein, a carbohydrate, a nucleotide and a nucleic acid, with the proviso that at least one of R4, R5, R6, R7 or R8 is -LM.
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公开(公告)号：US20230333095A1
公开(公告)日：2023-10-19
申请号：US18339799
申请日：2023-06-22
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Maksim Fomin , Dieter Heindl , Lars Hillringhaus , Hannes Kuchelmeister , Mohamed Yosry Hassan Mohamed , Tobias Oelschlaegel , Sona Simonyiova
IPC: G01N33/533 , G01N33/68 , C07F15/02
CPC classification number: G01N33/533 , G01N33/6887 , C07F15/025 , G01N2800/325
Abstract: The present invention relates to a method for determining at least one analyte of interest. The present invention further relates to a kit, a complex, a method to synthesize a complex and the use thereof for detecting the analyte of interest in the sample.
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公开(公告)号：US20210017272A1
公开(公告)日：2021-01-21
申请号：US16825181
申请日：2020-03-20
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Tobias Oelschlaegel , Pavel Kubalec
Abstract: The present disclosure relates to novel analyte-specific multivalent recombinant antibodies that are particularly useful in immunoassays. Specifically, hexavalent, octavalent and decavalent antibodies are disclosed, including their construction, production, characterization and use in target antigen detection assays.
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Patent Agency Ranking
公开(公告)号：US20240343833A1
公开(公告)日：2024-10-17
申请号：US18752484
申请日：2024-06-24
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Mohamed Yosry Hassan Mohamed , Tobias Oelschlaegel
CPC classification number: C07K16/40 , C12Y203/02013 , G01N33/6854 , C07K2317/20 , C07K2317/21 , C07K2317/24 , C07K2317/622 , C07K2319/60
Abstract: The present invention relates to a modified antibody comprising a heavy chain and a light chain, wherein the antibody is modified to include in one or more of its immunoglobulin polypeptide chains one or more first recognition site(s) for the transglutaminase from Kutzneria albida (KalbTG) or a functionally active variant thereof. The one or more first recognition site(s) are introduced at one or more selected position(s) within an antibody's heavy chain and/or an antibody's light chain. The invention further relates to one or more nucleic acid(s) encoding an immunoglobulin polypeptide chain including the one or more recognition site(s), a site-specifically conjugated antibody comprising the modified antibody and one or more labelling domain(s) covalently attached to one or more first recognition sites, a kit for producing the conjugated antibody, a method of specifically labelling the modified antibody by way of site-specific conjugation, the use of the modified antibody for producing a specifically site-specifically conjugated antibody, a method of detecting a target in a sample and the use of the site-specifically conjugated antibody in the detection of a target and/or in the diagnosis.
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6.发明授权公开(公告)号：US11136376B2
公开(公告)日：2021-10-05
申请号：US15934055
申请日：2018-03-23
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Alfred Engel , Pavel Kubalec , Alfons Nichtl , Tobias Oelschlaegel , Rainer Schlecht
IPC: C07K16/00
Abstract: The disclosure describes a recombinant immunoglobulin heavy chain comprising a sortase conjugation loop, methods for conjugating and/or labeling such recombinant immunoglobulin heavy chains by use of the enzyme sortase and to the conjugates/labeled products obtained via the method.
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公开(公告)号：US20200024292A1
公开(公告)日：2020-01-23
申请号：US16284346
申请日：2019-02-25
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Hans-Peter Josel , Tobias Oelschlaegel , Giuseppe Prencipe , Luisa De Cola , Elena Longhi , Chien-Wei Hsu
Abstract: The present disclosure relates to novel multifunctionalized silicon nanoparticles, to processes for their preparation and to compositions comprising the novel multifunctionalized silicon nanoparticles. The disclosure also relates to the use of the novel multifunctionalized silicon nanoparticles in electrochemiluminescence based detection methods and in the in vitro detection of an analyte. In particular, the disclosure relates to methods for measuring an analyte by in vitro methods employing the novel multifunctionalized silicon nanoparticles.
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公开(公告)号：US20240352110A1
公开(公告)日：2024-10-24
申请号：US18745539
申请日：2024-06-17
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Alexander Jethwa , Tobias Oelschlaegel , Corinna Schindler , Monika Soukupova , Laura Stoeckl , Christina Zimmermann
IPC: C07K16/18 , G01N33/543 , G01N33/68
CPC classification number: C07K16/18 , G01N33/543 , G01N33/6896 , C07K2317/565 , G01N2333/4709 , G01N2470/04
Abstract: The present invention relates to a monoclonal antibody or an antigen-binding fragment thereof specifically binding to Aβ42 with advantageous features for Aβ42 detection in vitro using immunoassays. Also provided is a polynucleotide or a set of polynucleotides encoding the same and a vector comprising said polynucleotide(s). Further provided is a host cell comprising the polynucleotide(s) and a corresponding production process using this host cell. Also provided herein are uses and methods employing the monoclonal antibody or an antigen-binding fragment thereof specifically binding to Aβ42 as provided herein.
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9.发明申请公开(公告)号：US20210009660A1
公开(公告)日：2021-01-14
申请号：US15934055
申请日：2018-03-23
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Alfred Engel , Pavel Kubalec , Alfons Nichtl , Tobias Oelschlaegel , Rainer Schlecht
IPC: C07K16/00
Abstract: The disclosure describes a recombinant immunoglobulin heavy chain comprising a sortase conjugation loop, methods for conjugating and/or labeling such recombinant immunoglobulin heavy chains by use of the enzyme sortase and to the conjugates/labeled products obtained via the method.
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