公开(公告)号：US12140601B2

公开(公告)日：2024-11-12

申请号：US16714865

申请日：2019-12-16

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Juliane Drobnik ,  Mirko Klingauf ,  Regula Krieg

IPC: G01N35/00 ,  G01N35/04

Abstract: A computer-implemented method of automatically managing calibration of an in-vitro diagnostic system is provided comprising determining a lot calibration time period in which a lot calibration is applicable to reagent containers of the same lot, having a predefined time length starting from the time when the lot calibration becomes available, upon making a reagent container of the lot available to the system, determining whether a lot calibration that has not exceeded the lot calibration time period is available and linking the reagent container to the available lot calibration or most recent available lot calibration if more than one lot calibration is available, wherein if a new lot calibration for the same lot becomes available the method comprises replacing the existing link to the previous lot calibration with a link to the new lot calibration.

公开(公告)号：US20190094249A1

公开(公告)日：2019-03-28

申请号：US16136727

申请日：2018-09-20

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Mirko Klingauf

IPC: G01N35/00

Abstract: A computer-implemented method of calibrating an in-vitro diagnostic analyzer is disclosed. The method comprises executing a multi-point calibration procedure comprising measuring a plurality of calibrator levels and thereby obtaining a plurality of respective calibration points. The method further comprises calculating a result of the multi-point calibration procedure and determining failure or passing of the multi-point calibration procedure based on the calculated result. In case of failure of the multi-point calibration procedure, the method comprises determining if failure is related to one or more individual failed calibration point(s), and in the affirmative, triggering a repetition of measuring the calibrator level(s) only with respect to the failed calibration point(s) and re-calculating the result of the multi-point calibration procedure after replacing only the failed calibration point(s) with the newly obtained calibration point(s).

公开(公告)号：US11002749B2

公开(公告)日：2021-05-11

申请号：US16136727

申请日：2018-09-20

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Mirko Klingauf

IPC: G01N35/00

Abstract: A computer-implemented method of calibrating an in-vitro diagnostic analyzer is disclosed. The method includes executing a multi-point calibration procedure including measuring a plurality of calibrator levels and thereby obtaining a plurality of respective calibration points. The method further includes calculating a result of the multi-point calibration procedure and determining failure or passing of the multi-point calibration procedure based on the calculated result. In case of failure of the multi-point calibration procedure, the method includes determining if failure is related to one or more individual failed calibration point(s), and in the affirmative, triggering a repetition of measuring the calibrator level(s) only with respect to the failed calibration point(s) and re-calculating the result of the multi-point calibration procedure after replacing only the failed calibration point(s) with the newly obtained calibration point(s).

公开(公告)号：US20210170390A1

公开(公告)日：2021-06-10

申请号：US17099884

申请日：2020-11-17

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Ronald Egli ,  Mirko Klingauf ,  Daniel Ott ,  Jerome Wiss

IPC: B01L3/02 ,  G01N7/00 ,  G01N33/50

Abstract: An in-vitro diagnostic device including a pipetting unit and a pipetting method, which allow for a more reproducible and more precise pipetting of liquids, when piercing through a lid of a closed liquid container is required. The pipetting unit is controlled to repeat penetration of the lid of the closed liquid container if the pressure difference between the interior of the liquid container and the surrounding is outside an allowable predefined pressure range.