公开(公告)号：US20230296623A1

公开(公告)日：2023-09-21

申请号：US18017073

申请日：2021-07-16

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Torbjoern Omland ,  Ursula-Henrike Wienhues-Thelen ,  Andre Ziegler

IPC: G01N33/68 ,  G01N33/569

CPC classification number: G01N33/6893 ,  G01N33/56983 ,  G01N2800/56

Abstract: The present invention relates to a method for predicting the disease severity in a patient with COVID-19, said method comprising a) determining the level of GDF-15 in a sample from the patient with COVID-19, b) comparing the level determined in step a) to a reference, and predicting the disease severity in a patient with COVID-19. Also encompassed are methods for risk stratification, monitoring of the disease progression and the risk prediction for hospital admission in a patient with COVID-19. Furthermore, methods are provided for predicting the need for intensive care, the risk for thrombosis, pulmonary embolism, hypoxia and mortality in a patient with COVID-19.