公开(公告)号：US20180003710A1

公开(公告)日：2018-01-04

申请号：US15673976

申请日：2017-08-10

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Herbert Andres ,  Stefan Weiser ,  Johann Karl ,  Ursula Kunert ,  Florian Grupp

IPC: G01N33/564 ,  G01N33/563 ,  G01N33/58

CPC classification number: G01N33/564 ,  G01N33/563 ,  G01N33/58 ,  G01N2333/91215 ,  G01N2800/102

Abstract: The present invention relates to a method aiding in the assessment of rheumatoid arthritis (“RA”). The method is used in assessing RA in vitro. It is practiced by analyzing biochemical markers, comprising measuring the concentration of anti-CCP and anti-PIK3CD and correlating the concentrations determined to the absence or presence of RA. The invention also relates to the use of a marker panel comprising anti-CCP and anti-PIK3CD in the diagnosis of RA and it teaches a kit for performing the method of the invention. Further the invention relates to the use of a marker panel comprising anti-CCP and anti-PIK3CD to differentiate RA from other autoimmune diseases, preferably osteoarthritis (OA).

公开(公告)号：US20180364230A1

公开(公告)日：2018-12-20

申请号：US16111347

申请日：2018-08-24

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Herbert Andres ,  Johann Karl ,  Ursula Kunert ,  David Morgenstern ,  Nina Meissler ,  Marion Niessner ,  Magdalena Swiatek-de Lange

IPC: G01N33/564 ,  G01N33/574 ,  C07K16/46

Abstract: The disclosure relates to an in vitro method for detecting an antibody to p53 (anti-p53 antibody) in a sample, the method comprising: incubating a sample to be analyzed with a p53 capture antigen and a p53 detection antigen, whereby a complex comprising the p53 capture antigen, the anti-p53 antibody and the p53 detection antigen is formed, separating the complex formed from unbound detection antigen and measuring the complex obtained via the detection antigen comprised therein, thereby detecting the anti-p53 antibody comprised in the sample.

公开(公告)号：US10094826B2

公开(公告)日：2018-10-09

申请号：US15673976

申请日：2017-08-10

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Herbert Andres ,  Stefan Weiser ,  Johann Karl ,  Ursula Kunert ,  Florian Grupp

IPC: G01N33/53 ,  G01N33/564 ,  G01N33/563 ,  G01N33/58

Abstract: Described is a method aiding in the assessment of rheumatoid arthritis (“RA”). The method is used in assessing RA in vitro. It is practiced by analyzing biochemical markers, including measuring the concentration of anti-CCP and anti-PIK 3CD and correlating the concentrations determined to the absence or presence of RA. Also disclosed is the use of a marker panel including anti-CCP and anti-PIK3CD in the diagnosis of RA and it teaches a kit for performing the method. Also described is the use of a marker panel comprising anti-CCP and anti-PIK3CD to differentiate RA from other autoimmune diseases, preferably osteoarthritis (OA).

公开(公告)号：US20240272154A1

公开(公告)日：2024-08-15

申请号：US18616550

申请日：2024-03-26

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Herbert Andres ,  Johann Karl ,  Ursula Kunert ,  David Morgenstern ,  Nina Meissler ,  Marion Niessner ,  Magdalena Swiatek-de Lange

IPC: G01N33/564 ,  C07K16/46 ,  G01N33/574

CPC classification number: G01N33/564 ,  C07K16/46 ,  G01N33/574 ,  G01N33/5748 ,  G01N33/57496

Abstract: An in vitro method is disclosed for detecting an antibody to p53 (anti-p53 antibody) in a sample, the method comprising: incubating a sample to be analyzed with a p53 capture antigen and a p53 detection antigen, whereby a complex comprising the p53 capture antigen, the anti-p53 antibody and the p53 detection antigen is formed, separating the complex formed from unbound detection antigen and measuring the complex obtained via the detection antigen comprised therein, thereby detecting the anti-p53 antibody comprised in the sample.

公开(公告)号：US11971407B2

公开(公告)日：2024-04-30

申请号：US17730403

申请日：2022-04-27

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Herbert Andres ,  Johann Karl ,  Ursula Kunert ,  David Morgenstern ,  Nina Meissler ,  Marion Niessner ,  Magdalena Swiatek-de Lange

IPC: G01N33/53 ,  C07K16/46 ,  G01N33/564 ,  G01N33/574

CPC classification number: G01N33/564 ,  C07K16/46 ,  G01N33/574 ,  G01N33/5748 ,  G01N33/57496

Abstract: An in vitro method is disclosed for detecting an antibody to p53 (anti-p53 antibody) in a sample, the method comprising: incubating a sample to be analyzed with a p53 capture antigen and a p53 detection antigen, whereby a complex comprising the p53 capture antigen, the anti-p53 antibody and the p53 detection antigen is formed, separating the complex formed from unbound detection antigen and measuring the complex obtained via the detection antigen comprised therein, thereby detecting the anti-p53 antibody comprised in the sample.

公开(公告)号：US20220252592A1

公开(公告)日：2022-08-11

申请号：US17730403

申请日：2022-04-27

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Herbert Andres ,  Johann Karl ,  Ursula Kunert ,  David Morgenstern ,  Nina Meissler ,  Marion Niessner ,  Magdalena Swiatek-de Lange

IPC: G01N33/564 ,  G01N33/574 ,  C07K16/46

Abstract: The disclosure relates to an in vitro method for detecting an antibody to p53 (anti-p53 antibody) in a sample, the method comprising: incubating a sample to be analyzed with a p53 capture antigen and a p53 detection antigen, whereby a complex comprising the p53 capture antigen, the anti-p53 antibody and the p53 detection antigen is formed, separating the complex formed from unbound detection antigen and measuring the complex obtained via the detection antigen comprised therein, thereby detecting the anti-p53 antibody comprised in the sample.