公开(公告)号：US20220229075A1

公开(公告)日：2022-07-21

申请号：US17613353

申请日：2020-05-22

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Kai HABBEN ,  Vinzent ROLNY ,  Anika MANG ,  Ursula-Henrike WIENHUES-THELEN ,  Serge MASSON

IPC: G01N33/74 ,  G01N33/68

Abstract: The present invention relates to a method for differentiating between heart failure with preserved ejection fraction (HFpEF) and heart failure with reduced ejection fraction (HFrEF) in a subject suffering from heart failure, said method comprising the steps of determining the amounts of IGFBP7 (Insulin-like growth factor-binding protein 7), of a BNP-type peptide, and optionally of CRP (C-reactive protein) in a sample from the subject, calculating (i) a ratio of the amount of IGFBP7 and the amount of the BNP-peptide or (ii) a ratio of the sum of the amounts of IGFBP7 and CRP and the amount of the BNP-type peptide, comparing the ratio calculated with a reference ratio, and differentiating between heart failure with preserved ejection fraction (HFpEF) and heart failure with reduced ejection fraction (HFrEF). The present invention further concerns a method for the diagnosis of HFpEF.