公开(公告)号：US20150293122A1

公开(公告)日：2015-10-15

申请号：US14540165

申请日：2014-11-13

申请人： Roche Diagnostics Operations, Inc. ,  The Governing Council of the University of Toronto

发明人： Ursula-Henrike Wienhues-Thelen ,  Georg Hess ,  Hendrik Huedig ,  Herbert von der Eltz ,  Andrew Emili ,  Anthony Gramolini ,  Peter Liu ,  David MacLennan ,  Vincent Fong ,  Ruth Isserlin ,  Thomas Kislinger ,  Dirk Block

IPC分类号： G01N33/68

CPC分类号： G01N33/6893 ,  G01N2333/47 ,  G01N2333/4727 ,  G01N2333/4737 ,  G01N2333/4745 ,  G01N2333/5412 ,  G01N2333/58 ,  G01N2800/325 ,  G01N2800/56

摘要： The invention relates to a method for assessing heart failure in vitro comprising the steps of measuring in a sample the concentration of the marker IGFBP-7, of optionally measuring in the sample the concentration of one or more other marker(s) of heart failure, and of assessing heart failure by comparing the concentration determined in for IGFBP-7 and the concentration(s) determined for the optionally one or more other marker to the concentration of this marker or these markers as established in a reference population. Also disclosed are the use of IGFBP-7 as a marker protein in the assessment of heart failure, a marker combination comprising IGFBP-7 and a kit for measuring IGFBP-7.

摘要翻译： 本发明涉及用于评估体外心脏衰竭的方法，包括以下步骤：在样品中测量标记物IGFBP-7的浓度，任选地在样品中测量一种或多种其他心力衰竭标志物的浓度， 并且通过比较在IGFBP-7中确定的浓度和为任选的一种或多种其它标记确定的浓度与在参考群体中确定的该标志物或这些标记的浓度进行比较来评估心力衰竭。 还公开了在评估心力衰竭中使用IGFBP-7作为标记蛋白，包括IGFBP-7的标记组合和用于测量IGFBP-7的试剂盒。

公开(公告)号：US20170016918A1

公开(公告)日：2017-01-19

申请号：US15285685

申请日：2016-10-05

申请人： Roche Diagnostics Operations, Inc. ,  The Governing Council of the University of Toronto

发明人： Ursula-Henrike Wienhues-Thelen ,  Georg Hess ,  Hendrik Huedig ,  Herbert von der Eltz ,  Andrew Emili ,  Anthony Gramolini ,  Peter Liu ,  David MacLennan ,  Vincent Fong ,  Ruth Isserlin ,  Thomas Kislinger ,  Dirk Block

IPC分类号： G01N33/68

CPC分类号： G01N33/6893 ,  G01N2333/47 ,  G01N2333/4727 ,  G01N2333/4737 ,  G01N2333/4745 ,  G01N2333/5412 ,  G01N2333/58 ,  G01N2800/325 ,  G01N2800/56

摘要： Disclosed is a method for assessing heart failure in vitro including the steps of measuring in a sample the concentration of the marker IGFBP-7, of optionally measuring in the sample the concentration of one or more other marker(s) of heart failure, and of assessing heart failure by comparing the concentration determined in for IGFBP-7 and the concentration(s) determined for the optionally one or more other marker to the concentration of this marker or these markers as established in a reference population. Also disclosed are the use of IGFBP-7 as a marker protein in the assessment of heart failure, a marker combination comprising IGFBP-7 and a kit for measuring IGFBP-7.

摘要翻译： 公开了一种用于评估体外心脏衰竭的方法，包括以下步骤：在样品中测量标记物IGFBP-7的浓度，任选地在样品中测量一种或多种其他心力衰竭标志物的浓度，以及 通过比较IGFBP-7中测定的浓度和将任选的一种或多种其它标记物测定的浓度与该参考群体中确定的该标记物或这些标记物的浓度进行比较来评估心力衰竭。 还公开了在评估心力衰竭中使用IGFBP-7作为标记蛋白，包括IGFBP-7的标记组合和用于测量IGFBP-7的试剂盒。

公开(公告)号：US10996229B2

公开(公告)日：2021-05-04

申请号：US16598361

申请日：2019-10-10

申请人： Roche Diagnostics Operations, Inc. ,  The Governing Council of the University of Toronto

发明人： Ursula-Henrike Wienhues-Thelen ,  Georg Hess ,  Hendrik Huedig ,  Herbert von der Eltz ,  Andrew Emili ,  Anthony Gramolini ,  Peter Liu ,  David MacLennan ,  Vincent Fong ,  Ruth Isserlin ,  Thomas Kislinger ,  Dirk Block

IPC分类号： G01N33/53 ,  G01N33/68

摘要： Disclosed is a method for assessing heart failure in vitro including the steps of measuring in a sample the concentration of the marker IGFBP-7, of optionally measuring in the sample the concentration of one or more other marker(s) of heart failure, and of assessing heart failure by comparing the concentration determined in for IGFBP-7 and the concentration(s) determined for the optionally one or more other marker to the concentration of this marker or these markers as established in a reference population. Also disclosed are the use of IGFBP-7 as a marker protein in the assessment of heart failure, a marker combination comprising IGFBP-7 and a kit for measuring IGFBP-7.

公开(公告)号：US20200064359A1

公开(公告)日：2020-02-27

申请号：US16598361

申请日：2019-10-10

申请人： Roche Diagnostics Operations, Inc. ,  The Governing Council of the University of Toronto

发明人： Ursula-Henrike Wienhues-Thelen ,  Georg Hess ,  Hendrik Huedig ,  Herbert von der Eltz ,  Andrew Emili ,  Anthony Gramolini ,  Peter Liu ,  David MacLennan ,  Vincent Fong ,  Ruth Isserlin ,  Thomas Kislinger ,  Dirk Block

IPC分类号： G01N33/68

摘要： Disclosed is a method for assessing heart failure in vitro including the steps of measuring in a sample the concentration of the marker IGFBP-7, of optionally measuring in the sample the concentration of one or more other marker(s) of heart failure, and of assessing heart failure by comparing the concentration determined in for IGFBP-7 and the concentration(s) determined for the optionally one or more other marker to the concentration of this marker or these markers as established in a reference population. Also disclosed are the use of IGFBP-7 as a marker protein in the assessment of heart failure, a marker combination comprising IGFBP-7 and a kit for measuring IGFBP-7.