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公开(公告)号:US20190002564A1
公开(公告)日:2019-01-03
申请号:US16134391
申请日:2018-09-18
申请人: Roche Glycart AG
发明人: Marina BACAC , Thomas HOFER , Ralf HOSSE , Christiane NEUMANN , Christian KLEIN , Ekkehard MOESSNER , Pablo UMANA , Tina WEINZIERL
摘要: The present invention generally relates to novel bispecific antigen binding molecules for T cell activation and re-direction to specific target cells. In addition, the present invention relates to polynucleotides encoding such bispecific antigen binding molecules, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the bispecific antigen binding molecules of the invention, and to methods of using these bispecific antigen binding molecules in the treatment of disease.
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公开(公告)号:US20210253703A1
公开(公告)日:2021-08-19
申请号:US17306068
申请日:2021-05-03
申请人: Roche Glycart AG
发明人: Marina BACAC , Thomas HOFER , Ralf HOSSE , Christiane NEUMANN , Christian KLEIN , Ekkehard MOESSNER , Pablo UMANA , Tina WEINZIERL
摘要: The present invention generally relates to novel bispecific antigen binding molecules for T cell activation and re-direction to specific target cells. In addition, the present invention relates to polynucleotides encoding such bispecific antigen binding molecules, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the bispecific antigen binding molecules of the invention, and to methods of using these bispecific antigen binding molecules in the treatment of disease.
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公开(公告)号:US20210101979A1
公开(公告)日:2021-04-08
申请号:US17127291
申请日:2020-12-18
申请人: Roche Glycart AG
发明人: Marina BACAC , Thomas HOFER , Ralf HOSSE , Christiane NEUMANN , Christian KLEIN , Ekkehard MOESSNER , Pablo UMANA , Tina WEINZIERL
摘要: The present invention generally relates to novel bispecific antigen binding molecules for T cell activation and re-direction to specific target cells. In addition, the present invention relates to polynucleotides encoding such bispecific antigen binding molecules, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the bispecific antigen binding molecules of the invention, and to methods of using these bispecific antigen binding molecules in the treatment of disease.
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公开(公告)号:US20230076791A1
公开(公告)日:2023-03-09
申请号:US17824628
申请日:2022-05-25
申请人: Roche Glycart AG
发明人: Marina BACAC , Thomas HOFER , Ralf HOSSE , Christiane NEUMANN , Christian KLEIN , Ekkehard MOESSNER , Pablo UMANA , Tina WEINZIERL
摘要: The present invention generally relates to novel bispecific antigen binding molecules for T cell activation and re-direction to specific target cells. In addition, the present invention relates to polynucleotides encoding such bispecific antigen binding molecules, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the bispecific antigen binding molecules of the invention, and to methods of using these bispecific antigen binding molecules in the treatment of disease.
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公开(公告)号:US20220064296A1
公开(公告)日:2022-03-03
申请号:US17525101
申请日:2021-11-12
申请人: Roche Glycart AG
发明人: Marina BACAC , Thomas HOFER , Ralf HOSSE , Christiane NEUMANN , Christian KLEIN , Ekkehard MOESSNER , Pablo UMANA , Tina WEINZIERL
摘要: The present invention generally relates to novel bispecific antigen binding molecules for T cell activation and re-direction to specific target cells. In addition, the present invention relates to polynucleotides encoding such bispecific antigen binding molecules, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the bispecific antigen binding molecules of the invention, and to methods of using these bispecific antigen binding molecules in the treatment of disease.
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