专利检索 ap:("Roland E. Dolle" OR "Bertrand Le Bourdonnec" OR "Christopher W. Ajello" OR "Minghua Gu" OR "Guo-Hua Chu" OR "Paul Anson Tuthill, Sr." OR "Lara K. Leister" OR "Q. Jean Zhou") AND inv:"Paul Anson Tuthill, Sr." 第 1 页

1.

发明授权
Spirocyclic heterocyclic derivatives and methods of their use 有权

公开(公告)号：US07563802B2

公开(公告)日：2009-07-21

申请号：US11960845

申请日：2007-12-20

申请人： Roland E. Dolle , Bertrand Le Bourdonnec , Christopher W. Ajello , Minghua Gu , Guo-Hua Chu , Paul Anson Tuthill, Sr. , Lara K. Leister , Q. Jean Zhou

发明人： Roland E. Dolle , Bertrand Le Bourdonnec , Christopher W. Ajello , Minghua Gu , Guo-Hua Chu , Paul Anson Tuthill, Sr. , Lara K. Leister , Q. Jean Zhou

IPC分类号： A61K31/438 , C07D491/10

摘要： Spirocyclic heterocyclic derivatives, pharmaceutical compositions containing these compounds, and methods for their pharmaceutical use are disclosed. In certain embodiments, the spirocyclic heterocyclic derivatives are ligands of the δ opioid receptor and may be useful, inter alia, for treating and/or preventing pain, anxiety, gastrointestinal disorders, and other δ opioid receptor-mediated conditions.