公开(公告)号：US20100196269A1

公开(公告)日：2010-08-05

申请号：US12509549

申请日：2009-07-27

Applicant: Roland E. Dolle ,  Bertrand Le Bourdonnec ,  Guo-Hua Chu

Inventor： Roland E. Dolle ,  Bertrand Le Bourdonnec ,  Guo-Hua Chu

IPC: A61K31/55 ,  C07D405/04 ,  A61K31/438 ,  C07D221/20 ,  A61K31/5377 ,  A61K51/04 ,  A61P1/02 ,  A61P25/00 ,  A61P29/00

CPC classification number: C07D491/107 ,  C07D487/10

Abstract: Spirocyclic heterocyclic derivatives, pharmaceutical compositions containing these compounds, and methods for their pharmaceutical use are disclosed. In certain embodiments, the spirocyclic heterocyclic derivatives are ligands of the δ-opioid receptor and may be useful, inter alia, for treating and/or preventing pain, anxiety, gastrointestinal disorders, and other δ-opioid receptor-mediated diseases, disorders, and/or conditions.

Abstract translation: 公开了螺环杂环衍生物，含有这些化合物的药物组合物及其制药方法。 在某些实施方案中，螺环杂环衍生物是δ-阿片受体受体的配体，尤其可用于治疗和/或预防疼痛，焦虑，胃肠道疾病和其他δ-阿片受体介导的疾病，病症和 /或条件。

公开(公告)号：US07906646B2

公开(公告)日：2011-03-15

申请号：US12483781

申请日：2009-06-12

Applicant: Roland E. Dolle ,  Bertrand Le Bourdonnec ,  Guo-Hua Chu

Inventor： Roland E. Dolle ,  Bertrand Le Bourdonnec ,  Guo-Hua Chu

IPC: A61K31/438 ,  C07D401/06 ,  C07D403/04

CPC classification number: C07D491/107 ,  C07D221/20 ,  C07D311/96 ,  C07D401/04 ,  C07D493/10 ,  C07D495/10

Abstract: Spirocyclic heterocyclic derivatives, pharmaceutical compositions containing these compounds, and methods for their pharmaceutical use are disclosed. In certain embodiments, the spirocyclic heterocyclic derivatives are ligands of the δ opioid receptor and may be useful, inter alia, for treating and/or preventing pain, anxiety, gastrointestinal disorders, and other δ opioid receptor-mediated conditions.

公开(公告)号：US20070269374A1

公开(公告)日：2007-11-22

申请号：US11696585

申请日：2007-04-04

Applicant: Roland Dolle ,  Bertrand Le Bourdonnec ,  Guo-Hua Chu

Inventor： Roland Dolle ,  Bertrand Le Bourdonnec ,  Guo-Hua Chu

IPC: A61K31/438 ,  A61K31/015 ,  A61K31/135 ,  A61K31/33 ,  A61K31/4523 ,  A61K31/4748 ,  A61K31/5375 ,  A61K51/04 ,  A61P15/00 ,  A61P29/00 ,  A61P25/36 ,  A61P25/34 ,  A61P25/32 ,  A61P25/24 ,  A61P25/22 ,  A61P25/16 ,  A61P25/14 ,  A61P25/00 ,  C07D401/04 ,  A61P9/12 ,  A61P9/10 ,  A61P9/00 ,  A61P37/00 ,  A61P11/06 ,  A61K31/5377 ,  A61K31/485 ,  A61K31/4545 ,  A61K31/445 ,  A61K31/381 ,  A61K31/4166

CPC classification number: C07D491/107 ,  C07D487/10

Abstract: Spirocyclic heterocyclic derivatives, pharmaceutical compositions containing these compounds, and methods for their pharmaceutical use are disclosed. In certain embodiments, the spirocyclic heterocyclic derivatives are ligands of the δ-opioid receptor and may be useful, inter alia, for treating and/or preventing pain, anxiety, gastrointestinal disorders, and other δ-opioid receptor-mediated diseases, disorders, and/or conditions.

Abstract translation: 公开了螺环杂环衍生物，含有这些化合物的药物组合物及其制药方法。 在某些实施方案中，螺环杂环衍生物是δ-阿片受体受体的配体，尤其可用于治疗和/或预防疼痛，焦虑，胃肠道疾病和其他δ-阿片受体介导的疾病，病症和 /或条件。

公开(公告)号：US07160902B2

公开(公告)日：2007-01-09

申请号：US10713746

申请日：2003-11-14

Applicant: Roland E. Dolle ,  Guo-Hua Chu ,  Minghua Gu

Inventor： Roland E. Dolle ,  Guo-Hua Chu ,  Minghua Gu

IPC: C07D207/12 ,  C07D401/06 ,  C07D403/12 ,  C07D417/12 ,  A61K31/40 ,  A61K31/427 ,  A61K31/4439 ,  A61K31/454

CPC classification number: C07D207/48 ,  C07C233/36 ,  C07D207/12 ,  C07D401/06 ,  C07D401/12 ,  C07D403/12 ,  C07D417/12

Abstract: Amide derivatives of the general formulae Ia and Ib: are disclosed. Pharmaceutical compositions containing these compounds, and methods for their use, inter alia, for treating and/or preventing gastrointestinal disorders, pain, and pruritus are also disclosed.

Abstract translation: 公开了通式Ia和Ib的酰胺衍生物。 还公开了含有这些化合物的药物组合物及其用于治疗和/或预防胃肠道疾病，疼痛和瘙痒的方法。

公开(公告)号：US20050107355A1

公开(公告)日：2005-05-19

申请号：US10713746

申请日：2003-11-14

Applicant: Roland Dolle ,  Guo-Hua Chu ,  Minghua Gu

Inventor： Roland Dolle ,  Guo-Hua Chu ,  Minghua Gu

IPC: A61K31/165 ,  A61K31/167 ,  A61K31/397 ,  A61K31/40 ,  A61K31/445 ,  C07C233/36 ,  C07C237/20 ,  C07D207/12 ,  C07D207/48 ,  C07D401/06 ,  C07D401/12 ,  C07D403/12 ,  C07D417/12

CPC classification number: C07D207/48 ,  C07C233/36 ,  C07D207/12 ,  C07D401/06 ,  C07D401/12 ,  C07D403/12 ,  C07D417/12

Abstract: Amide derivatives of the general formulae Ia and Ib: are disclosed. Pharmaceutical compositions containing these compounds, and methods for their use, inter alia, for treating and/or preventing gastrointestinal disorders, pain, and pruritus are also disclosed.

Abstract translation: 公开了通式Ia和Ib的酰胺衍生物。 还公开了含有这些化合物的药物组合物及其用于治疗和/或预防胃肠道疾病，疼痛和瘙痒的方法。

公开(公告)号：US20100120808A1

公开(公告)日：2010-05-13

申请号：US12483781

申请日：2009-06-12

Applicant: Roland E. Dolle ,  Bertrand Le Bourdonnec ,  Guo-Hua Chu

Inventor： Roland E. Dolle ,  Bertrand Le Bourdonnec ,  Guo-Hua Chu

IPC: A61K31/438 ,  C07D401/02 ,  A61P1/00 ,  A61P37/02 ,  A61P25/04 ,  A61P9/12

CPC classification number: C07D491/107 ,  C07D221/20 ,  C07D311/96 ,  C07D401/04 ,  C07D493/10 ,  C07D495/10

Abstract: Spirocyclic heterocyclic derivatives, pharmaceutical compositions containing these compounds, and methods for their pharmaceutical use are disclosed. In certain embodiments, the spirocyclic heterocyclic derivatives are ligands of the δ opioid receptor and may be useful, inter alia, for treating and/or preventing pain, anxiety, gastrointestinal disorders, and other δ opioid receptor-mediated conditions.

公开(公告)号：US07576207B2

公开(公告)日：2009-08-18

申请号：US11696585

申请日：2007-04-04

Applicant: Roland E. Dolle ,  Bertrand Le Bourdonnec ,  Guo-Hua Chu

Inventor： Roland E. Dolle ,  Bertrand Le Bourdonnec ,  Guo-Hua Chu

IPC: C07D401/00 ,  A01N43/42

CPC classification number: C07D491/107 ,  C07D487/10

Abstract: Spirocyclic heterocyclic derivatives, pharmaceutical compositions containing these compounds, and methods for their pharmaceutical use are disclosed. In certain embodiments, the spirocyclic heterocyclic derivatives are ligands of the δ-opioid receptor and may be useful, inter alia, for treating and/or preventing pain, anxiety, gastrointestinal disorders, and other δ-opioid receptor-mediated diseases, disorders, and/or conditions.

Abstract translation: 公开了螺环杂环衍生物，含有这些化合物的药物组合物及其制药方法。 在某些实施方案中，螺环杂环衍生物是δ-阿片受体受体的配体，尤其可用于治疗和/或预防疼痛，焦虑，胃肠道疾病和其他δ-阿片受体介导的疾病，病症和 /或条件。

公开(公告)号：US20050054630A1

公开(公告)日：2005-03-10

申请号：US10651197

申请日：2003-08-28

Applicant: Roland Dolle ,  Guo-Hua Chu

Inventor： Roland Dolle ,  Guo-Hua Chu

IPC: A61K31/397 ,  A61K31/40 ,  A61K31/4025 ,  A61K31/452 ,  C07D207/12 ,  C07D403/12 ,  C07D405/00 ,  C07D405/12 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D45/02

CPC classification number: C07D405/12 ,  C07D207/12 ,  C07D403/12 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14

Abstract: Fused bicyclic carboxamide derivatives are disclosed. Pharmaceutical compositions containing the compounds and methods for their use are also disclosed.

Abstract translation: 公开了稠合的二环甲酰胺衍生物。 还公开了含有这些化合物的药物组合物及其使用方法。

公开(公告)号：US08022060B2

公开(公告)日：2011-09-20

申请号：US12542302

申请日：2009-08-17

Applicant: Roland E. Dolle ,  Bertrand Le Bourdonnec ,  Guo-Hua Chu

Inventor： Roland E. Dolle ,  Bertrand Le Bourdonnec ,  Guo-Hua Chu

IPC: A61K31/55 ,  C07D491/107

CPC classification number: C07D491/10 ,  C07D221/20 ,  C07D223/14 ,  C07D311/96 ,  C07D493/10 ,  C07D495/10

Abstract: Spirocyclic heterocyclic derivatives, pharmaceutical compositions containing these compounds, and methods for their pharmaceutical use are disclosed. In certain embodiments, the spirocyclic heterocyclic derivatives are ligands of the δ opioid receptor and may be useful, inter alia, for treating and/or preventing pain, anxiety, gastrointestinal disorders, and other δ opioid receptor-mediated conditions.

Abstract translation: 公开了螺环杂环衍生物，含有这些化合物的药物组合物及其制药方法。 在某些实施方案中，螺环杂环衍生物是δ阿片样受体的配体，尤其可用于治疗和/或预防疼痛，焦虑，胃肠道疾病和其他δ阿片受体介导的病症。

公开(公告)号：US20100029614A1

公开(公告)日：2010-02-04

申请号：US12542302

申请日：2009-08-17

Applicant: Roland E. Dolle ,  Bertrand Le Bourdonnec ,  Guo-Hua Chu

Inventor： Roland E. Dolle ,  Bertrand Le Bourdonnec ,  Guo-Hua Chu

IPC: A61K31/438 ,  C07D491/107 ,  C07D307/94 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/55 ,  A61K31/352

CPC classification number: C07D491/10 ,  C07D221/20 ,  C07D223/14 ,  C07D311/96 ,  C07D493/10 ,  C07D495/10

Abstract: Spirocyclic heterocyclic derivatives, pharmaceutical compositions containing these compounds, and methods for their pharmaceutical use are disclosed. In certain embodiments, the spirocyclic heterocyclic derivatives are ligands of the δ opioid receptor and may be useful, inter alia, for treating and/or preventing pain, anxiety, gastrointestinal disorders, and other δ opioid receptor-mediated conditions.

Abstract translation: 公开了螺环杂环衍生物，含有这些化合物的药物组合物及其制药方法。 在某些实施方案中，螺环杂环衍生物是δ阿片受体受体的配体，尤其可用于治疗和/或预防疼痛，焦虑，胃肠道疾病和其他δ阿片受体介导的病症。