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    DIAGNOSIS OF FETAL ABNORMALITIES BY COMPARATIVE GENOMIC HYBRIDIZATION ANALYSIS
    1.
    发明申请
    DIAGNOSIS OF FETAL ABNORMALITIES BY COMPARATIVE GENOMIC HYBRIDIZATION ANALYSIS 审中-公开
    通过比较基因组杂交分析诊断不典型性

    公开(公告)号：US20100112586A1

    公开(公告)日：2010-05-06

    申请号：US12608876

    申请日：2009-10-29

    申请人： Roland STOUGHTON ,  Ravi Kapur

    发明人： Roland STOUGHTON ,  Ravi Kapur

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6809 ,  C12Q1/6827 ,  C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/158 ,  G01N2015/1006 ,  G01N2015/1087

    摘要： The present invention provides systems, apparatuses, and methods to detect the presence of fetal cells when mixed with a population of maternal cells in a sample and to test fetal abnormalities, e.g. aneuploidy. The present invention involves performing comparative genomic hybridization (CGH) analysis when fetal cells are present in a mixed population of cells. The present invention involves detecting the presence of fetal cells in a mixed maternal sample by detecting the presence of non-maternal alleles in said sample. Furthermore, the present invention also involves correlating the presence of fetal cells in a mixed sample with CGH analysis results to detect a fetal abnormality or declare a test non-informative.

    摘要翻译： 本发明提供了当与样品中的母体细胞群混合时检测胎儿细胞的存在并测试胎儿异常的系统，装置和方法，例如， 非整倍体 当胎儿细胞存在于混合细胞群体中时，本发明涉及进行比较基因组杂交（CGH）分析。 本发明涉及通过检测所述样品中非母体等位基因的存在来检测混合母体样品中胎儿细胞的存在。 此外，本发明还涉及将混合样品中的胎儿细胞的存在与CGH分析结果相关联以检测胎儿异常或者宣布测试非信息。

    Diagnosis of Fetal Abnormalities by Comparative Genomic Hybridization Analysis
    2.
    发明申请
    Diagnosis of Fetal Abnormalities by Comparative Genomic Hybridization Analysis 审中-公开
    通过比较基因组杂交分析诊断胎儿异常

    公开(公告)号：US20080026390A1

    公开(公告)日：2008-01-31

    申请号：US11763431

    申请日：2007-06-14

    申请人： Roland STOUGHTON ,  Ravi Kapur

    发明人： Roland STOUGHTON ,  Ravi Kapur

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6809 ,  C12Q1/6827 ,  C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/158 ,  G01N2015/1006 ,  G01N2015/1087

    摘要： The present invention provides systems, apparatuses, and methods to detect the presence of fetal cells when mixed with a population of maternal cells in a sample and to test fetal abnormalities, e.g. aneuploidy. The present invention involves performing comparative genomic hybridization (CGH) analysis when fetal cells are present in a mixed population of cells. The present invention involves detecting the presence of fetal cells in a mixed maternal sample by detecting the presence of non-maternal alleles in said sample. Furthermore, the present invention also involves correlating the presence of fetal cells in a mixed sample with CGH analysis results to detect a fetal abnormality or declare a test non-informative.

    摘要翻译： 本发明提供了当与样品中的母体细胞群混合时检测胎儿细胞的存在并测试胎儿异常的系统，装置和方法，例如， 非整倍体 当胎儿细胞存在于混合细胞群体中时，本发明涉及进行比较基因组杂交（CGH）分析。 本发明涉及通过检测所述样品中非母体等位基因的存在来检测混合母体样品中胎儿细胞的存在。 此外，本发明还涉及将混合样品中的胎儿细胞的存在与CGH分析结果相关联以检测胎儿异常或者宣布测试非信息。