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    Penicillin derivatives
    1.
    发明授权
    Penicillin derivatives 失效
    青霉素衍生物

    公开(公告)号：US4668514A

    公开(公告)日：1987-05-26

    申请号：US658373

    申请日：1984-10-05

    申请人： Ronald G. Micetich ,  Shigeru Yamabe ,  Motoaki Tanaka ,  Tomio Yamazaki ,  Naobumi Ishida ,  Makoto Kajitani

    发明人： Ronald G. Micetich ,  Shigeru Yamabe ,  Motoaki Tanaka ,  Tomio Yamazaki ,  Naobumi Ishida ,  Makoto Kajitani

    IPC分类号： C07D499/86 ,  A61K31/43 ,  C07D499/00 ,  A61K31/425

    CPC分类号： C07D499/00 ,  A61K31/43 ,  Y02P20/55

    摘要： This invention provides a penicillin derivative of the formula ##STR1## wherein R.sub.1 and R.sub.2 are the same or different and represent hydrogen, C.sub.1-6 alkyl, C.sub.1-6 hydroxyalkyl, C.sub.3-9 acyloxyalkyl, C.sub.8-13 benzyloxyalkyl, C.sub.2-7 alkoxyalkyl, C.sub.2-7 alkoxycarbonyl, C.sub.3-8 alkenyloxycarbonyl, C.sub.3-8 alkynyloxycarbonyl, phenyl, amino, cyano, formyl, trifluoromethyl, C.sub.2-6 acyl, carbamoyl, C.sub.2-7 alkylcarbamoyl, benzyloxycarbonylamino, C.sub.2-7 alkoxycarbonylamino; and R.sub.3 is hydrogen, a group for forming a pharmaceutically acceptable salt, or a penicillin carboxyl protecting group, with the proviso that both of R.sub.1 and R.sub.2 are not hydrogen or C.sub.2-7 alkoxycarbonyl at the same time and that when one of R.sub.1 and R.sub.2 is hydrogen, the other is not C.sub.2-7 alkoxycarbonyl, or a pharmaceutically acceptable acid addition salt, process for preparing the derivative, and a pharmaceutical composition containing the derivative.

    摘要翻译： 本发明提供了一种下式的青霉素衍生物，其中R1和R2相同或不同，代表氢，C1-6烷基，C1-6羟烷基，C3-9酰氧基烷基，C8-13苄氧基烷基，C2-7烷氧基烷基， C 2-8烷氧基羰基，C 3-8烯氧基羰基，C 3-8炔氧基羰基，苯基，氨基，氰基，甲酰基，三氟甲基，C 2-6酰基，氨基甲酰基，C 2-7烷基氨基甲酰基，苄氧基羰基氨基，C 2-7烷氧基羰基氨基; 并且R 3是氢，用于形成药学上可接受的盐的基团或青霉素羧基保护基，条件是R 1和R 2同时不是氢或C 2-7烷氧基羰基，并且当R 1和R 2之一 是氢，另一个不是C 2-7烷氧基羰基，或其药学上可接受的酸加成盐，制备衍生物的方法和含有该衍生物的药物组合物。

    Penicillin derivatives
    2.
    发明授权
    Penicillin derivatives 失效
    青霉素衍生物

    公开(公告)号：US4562073A

    公开(公告)日：1985-12-31

    申请号：US519491

    申请日：1983-08-01

    申请人： Ronald G. Micetich ,  Shigeru Yamabe ,  Motoaki Tanaka ,  Makoto Kajitani ,  Tomio Yamazaki ,  Naobumi Ishida

    发明人： Ronald G. Micetich ,  Shigeru Yamabe ,  Motoaki Tanaka ,  Makoto Kajitani ,  Tomio Yamazaki ,  Naobumi Ishida

    IPC分类号： C07D499/86 ,  C07D499/00 ,  C07F7/10 ,  A61K31/425

    CPC分类号： C07D499/00 ,  C07F7/10

    摘要： A penicillin derivative represented by the following formula ##STR1## wherein R.sub.1 is hydrogen or trialkylsilyl; R.sub.2 is hydrogen, trialkylsilyl or COOR.sub.2 ' wherein R.sub.2 ' is hydrogen, C.sub.1-18 alkyl, C.sub.2-7 alkoxymethyl, C.sub.3-8 alkylcarbonyloxymethyl, C.sub.4-9 alkylcarbonyloxyethyl, (C.sub.5-7 cycloalkyl)carbonyloxymethyl, C.sub.9-14 benzylcarbonyloxyalkyl, C.sub.3-8 alkoxycarbonylmethyl, C.sub.4-9 alkoxycarbonylethyl, phthalidyl, crotonolacton-4-yl, .gamma.-butyrolacton-4-yl, halogenated C.sub.1-6 alkyl substituted with 1 to 3 halogen atoms, C.sub.1-6 alkoxy- or nitro-substituted or unsubstituted benzyl, benzhydryl, tetrahydropyranyl, dimethylaminoethyl, dimethylchlorosilyl, trichlorosilyl, (5-substituted C.sub.1-6 alkyl or phenyl or unsubstituted-2-oxo-1,3-dioxoden-4-yl)methyl, C.sub.8-13 benzoyloxyalkyl or group for forming a pharmaceutically acceptable salt; and R.sub.3 has the same meaning as above R.sub.2 '.

    摘要翻译： 由下式（IMAGE）表示的青霉素衍生物，其中R1是氢或三烷基甲硅烷基; R2是氢，三烷基甲硅烷基或COOR2'，其中R2'是氢，C1-18烷基，C2-7烷氧基甲基，C3-8烷基羰氧基甲基，C4-9烷基羰氧基乙基，（C5-7环烷​​基）羰基氧基甲基，C9-14苄基羰氧基烷基，C3-8 烷氧基羰基甲基，C4-9烷氧基羰基乙基，苯酞基，巴豆酸内酯-4-基，γ-丁内酯-4-基，被1至3个卤素原子取代的卤代C 1-6烷基，C 1-6烷氧基或硝基取代或未取代的苄基，二苯甲基 ，四氢吡喃基，二甲基氨基乙基，二甲基氯甲硅烷基，三氯甲硅烷基，（5-取代的C 1-6烷基或苯基或未取代的-2-氧代-1,3-二氧杂环己烯-4-基）甲基，C8-13苯甲酰氧基烷基或用于形成药学上可接受的盐 ; 和R3具有与上述R2'相同的含义。

    Penicillin derivatives
    3.
    发明授权
    Penicillin derivatives 失效
    青霉素衍生物

    公开(公告)号：US4529592A

    公开(公告)日：1985-07-16

    申请号：US501560

    申请日：1983-06-06

    申请人： Ronald G. Micetich ,  Shigeru Yamabe ,  Tomio Yamazaki ,  Naobumi Ishida ,  Takeshi Ishizawa

    发明人： Ronald G. Micetich ,  Shigeru Yamabe ,  Tomio Yamazaki ,  Naobumi Ishida ,  Takeshi Ishizawa

    IPC分类号： C07D499/87 ,  A61K31/425 ,  A61K31/43 ,  A61P31/04 ,  A61P43/00 ,  C07D499/00 ,  C07D499/86 ,  C07D499/897 ,  C07F7/10

    CPC分类号： C07D499/00 ,  C07F7/10

    摘要： A penicillin derivative represented by the following formula ##STR1## wherein R.sub.1 and R.sub.2 are each the same or different and represent hydrogen, C.sub.1-18 alkyl, mononitro-substituted benzyl or group for forming a pharmaceutically acceptable salt and R.sub.3 is selected from the group consisting of hydrogen, C.sub.1-6 alkyl, C.sub.2-7 alkoxymethyl, C.sub.3-8 alkylcarbonyloxymethyl, C.sub.4-9 alkylcarbonyloxyethyl, (C.sub.5-7 cycloalkyl)carbonyloxymethyl, C.sub.9-14 benzylcarbonyloxyalkyl, C.sub.3-8 alkoxycarbonylmethyl, C.sub.4-9 alkoxycarbonylethyl, phthalidyl, crotonolacton-4-yl, .gamma.-butyrolacton-4-yl, halogenated C.sub.1-6 alkyl substituted with 1 to 3 halogen atoms, C.sub.1-6 alkoxy- or nitro-substituted or unsubstituted benzyl, benzhydryl, tetrahydropyranyl, dimethylaminoethyl, dimethylchlorosilyl, trichlorosilyl, (5-substituted C.sub.1-6 alkyl or phenyl or unsubstituted-2-oxo-1,3-dioxoden-4-yl)methyl, C.sub.8-13 benzoyloxyalkyl and group for forming a pharmaceutically acceptable salt.

    摘要翻译： 由下式（IMAGE）表示的青霉素衍生物，其中R 1和R 2各自相同或不同，表示氢，C 1-18烷基，一硝基取代的苄基或用于形成药学上可接受的盐的基团，R 3选自 氢，C 1-6烷基，C 2-7烷氧基甲基，C 3-8烷基羰基氧基甲基，C 4-9烷基羰基氧基乙基，（C 5-7环烷​​基）羰基氧基甲基，C 9-14苄基羰氧基烷基，C 3-8烷氧基羰基甲基，C 4-9烷氧基羰基乙基， 吡啶-4-基，γ-丁内酯-4-基，被1至3个卤素原子取代的卤代C 1-6烷基，C 1-6烷氧基或硝基取代或未取代的苄基，二苯甲基，四氢吡喃基，二甲基氨基乙基，二甲基氯甲硅烷基，三氯硅烷基（5 取代的C 1-6烷基或苯基或未取代的-2-氧代-1,3-二氧杂环己烯-4-基）甲基，C 13-13苯甲酰氧基烷基和用于形成药学上可接受的盐的基团。

    Penam derivatives
    4.
    发明授权
    Penam derivatives 失效
    Penam衍生物

    公开(公告)号：US4626384A

    公开(公告)日：1986-12-02

    申请号：US716948

    申请日：1985-03-28

    申请人： Motoaki Tanaka ,  Makoto Kajitani ,  Tomio Yamazaki

    发明人： Motoaki Tanaka ,  Makoto Kajitani ,  Tomio Yamazaki

    IPC分类号： C07D519/06 ,  A61K31/43 ,  A61P31/04 ,  C07D499/00 ,  C07D499/21 ,  C07D499/32 ,  C07D499/86 ,  C07D519/00

    CPC分类号： C07D499/00

    摘要： This invention provides a penam derivative represented by the formula ##STR1## wherein R is hydrogen or methyl and R.sub.1 is (hexahydro-1H-azepin-1-yl)methyleneamino, 2-phenylacetamido, 2-phenoxyacetamido, 2-amino-2-phenylacetamido, 2-amino-2-(p-hydroxyphenyl)acetamido or 2-(4-ethyl-2,3-dioxo-1-piperazine)carboxamido-2-phenylacetamido, and a salt thereof, and processes for preparing them.

    摘要翻译： 本发明提供由式（I）表示的对苯二甲酸衍生物，其中R是氢或甲基，R 1是（六氢-1H-吖庚因-1-基）亚甲基氨基，2-苯基乙酰氨基，2-苯氧基乙酰氨基， 2-氨基-2-（对羟基苯基）乙酰氨基或2-（4-乙基-2,3-二氧代-1-哌嗪）甲酰胺基-2-苯基乙酰氨基及其盐及其制备方法 。

    Baton twirling figure
    6.
    发明授权
    Baton twirling figure 失效
    巴吞布纹状图

    公开(公告)号：US4047325A

    公开(公告)日：1977-09-13

    申请号：US715242

    申请日：1976-06-18

    申请人： Tomio Yamazaki

    发明人： Tomio Yamazaki

    IPC分类号： A63H11/10 ,  A63H13/04

    CPC分类号： A63H11/10 ,  A63H13/04

    摘要： A baton twirling doll having a torso, arms, legs, and a head which are all connected so as to simulate the human body can be connected to a support structure used to provide power to move one or more parts of the body with respect to other parts of the body. The support structure used includes a wheeled platform and a support member extending from the platform to the torso of the doll. A mechanical drive is connected to the wheels of the platform so as to be operated when the platform is rolled along a surface. This drive is connected with a motion transmitting structure within the torso of the doll for moving at least one part of the doll relative to the remainder of the doll. Preferably the doll is constructed so that a hand on one of the arms of the doll is rotated as the arm holding this hand is rotated and so that the legs of the doll are moved to simulate normal leg movement as the wheeled platform is moved along a surface. With such a structure a baton may be held by the movable hand so that it will rotate to simulate normal baton movement as the platform is moved.

    摘要翻译： 具有躯干，手臂，腿部和头部的连接以模拟人体的指挥棒旋转娃娃可以连接到用于提供动力以相对于其他身体移动身体的一个或多个部分的动力的支撑结构 身体部位。 所使用的支撑结构包括从平台延伸到玩偶躯体的轮式平台和支撑构件。 机械驱动器连接到平台的车轮，以便当平台沿着表面滚动时被操作。 该驱动器与娃娃躯干内的运动传递结构连接，用于相对于娃娃的其余部分移动娃娃的至少一部分。 优选地，玩偶被构造成使得随着握住该手的手旋转的玩偶的一个臂上的手旋转，并且当轮式平台沿着移动的方向移动时，玩偶的腿被移动以模拟正常的腿部运动 表面。 通过这样的结构，可以通过可移动的手来保持指挥棒，使得它可以在平台移动时旋转以模拟正常的指挥棒运动。

    Flicker lamps for a car
    8.
    发明授权
    Flicker lamps for a car 失效
    汽车闪烁灯

    公开(公告)号：US4661800A

    公开(公告)日：1987-04-28

    申请号：US729322

    申请日：1985-05-01

    申请人： Tomio Yamazaki

    发明人： Tomio Yamazaki

    IPC分类号： B60Q1/34 ,  B60Q1/26 ,  B60R1/12 ,  B60Q1/00

    CPC分类号： B60Q1/2665 ,  B60R1/1207

    摘要： Flicker lamps for a car are disclosed, which are provided on the outer end of door mirrors or fender mirrors of the car, so that a driver of a motorcycle or the like running aside the car can readily recognize their flickering.

    摘要翻译： 公开了一种用于汽车的倒车灯，其设置在轿厢的后视镜或挡泥板反射镜的外端上，使得驾驶汽车的摩托车等的驾驶员能够容易地识别其闪烁。