公开(公告)号：US20170176440A1

公开(公告)日：2017-06-22

申请号：US15129597

申请日：2015-03-26

申请人： Rong LI ,  Bin YUAN ,  Qinong YE ,  Long CHENG

发明人： Rong LI ,  Bin YUAN ,  Qinong YE ,  Long CHENG

IPC分类号： G01N33/574 ,  C07K16/28

CPC分类号： G01N33/57415 ,  C07K16/2869 ,  C07K2317/30 ,  G01N2800/52

摘要： Embodiments are directed to methods of evaluating the prognosis of a breast cancer patient by assessing the level of phosphorylation tyrosine 36 of estrogen receptor beta (ERB). Certain embodiments are directed to methods for evaluating the prognosis of a cancer patient comprising contacting a breast cancer sample from a patient with stage II or stage III breast cancer with an antibody that binds phosphorylated tyrosine 36 of Ei¾β; quantifying phosphorylation of tyrosine 36 of EI¾β; and classifying the patient as having a good prognosis if phosphorylated tyrosine 36 levels are elevated or classifying the patient as having a poor prognosis if tyrosine levels are decreased relative to a non-cancer control. Certain embodiments are directed to an antibody or antibodies that specifically bind tyrosine 36 (Y36) of the ERp.