公开(公告)号：US06719999B2

公开(公告)日：2004-04-13

申请号：US09283083

申请日：1999-03-31

申请人： Rong (Ron) Liu ,  Qinghai Pan ,  Pawan Hansrani

发明人： Rong (Ron) Liu ,  Qinghai Pan ,  Pawan Hansrani

IPC分类号： A61K948

CPC分类号： A61K9/4858

摘要： The present invention is directed to a formulation comprising a lipid-regulating agent dissolved in one or more non-aqueous and/or water-miscible solvents, or optionally, in a premix of one or more solvents and one or more surfactants.

摘要翻译： 本发明涉及包含溶解在一种或多种非水和/或水混溶性溶剂中或任选在一种或多种溶剂和一种或多种表面活性剂的预混物中的脂质调节剂的制剂。

公开(公告)号：US06372251B2

公开(公告)日：2002-04-16

申请号：US09330589

申请日：1999-06-11

申请人： Rong Ron Liu ,  Qinghai Pan ,  Pawan Hansrani

发明人： Rong Ron Liu ,  Qinghai Pan ,  Pawan Hansrani

IPC分类号： A61K900

CPC分类号： A61K9/4858 ,  Y10S514/96 ,  Y10S514/962

摘要： The present invention is directed to a semi-solid formulation comprising a lipid-regulating agent. Said formulation is prepared by solubilizing said lipid-regulating agent in one or more liquid components to form a clear liquid solution, then solidifying said solution by adding one or more solid or semi-solid components to said solution to form a semi-solid formulation. Said formulation can melt or dissolve upon mixing with a bulk aqueous medium. The resulting formulation results in an increase in drug solubility and oral bioavailability, and an improved dissolution rate.

摘要翻译： 本发明涉及包含脂调节剂的半固体制剂。 所述制剂通过将所述脂调节剂溶解在一种或多种液体组分中以形成透明液体溶液来制备，然后通过向所述溶液中加入一种或多种固体或半固体组分来固化所述溶液以形成半固体制剂。 所述制剂在与大量水性介质混合时可熔化或溶解。 所得制剂导致药物溶解度和口服生物利用度的增加，以及改善的溶出速率。