公开(公告)号：US11814392B2

公开(公告)日：2023-11-14

申请号：US17514378

申请日：2021-10-29

Applicant: Rosalind Franklin University of Medicine and Science

Inventor： June A Mayor ,  Shivaputra A. Patil ,  Ronald S. Kaplan

IPC: C07D491/052 ,  A61P35/00

CPC classification number: C07D491/052 ,  A61P35/00

Abstract: Chromenopyridine-based compounds are provided. In one aspect, the present disclosure provides a method for treating cancer in a subject in need thereof, the method comprising administering a therapeutically effective amount of a chromenopyridine-based compound to the subject. A representative compound is 2,4-diamino-7,8-dimethoxy-5-((4-methoxyphenyl)thio)-5H-chromeno[2,3-b]pyridine-3-carbonitrile (Compound 1).