公开(公告)号：US20110137028A1

公开(公告)日：2011-06-09

申请号：US12910920

申请日：2010-10-25

申请人： Roy L. Harris ,  John Sapienza ,  Graziella Shevlin ,  Patrick Papa ,  Branden Gingsee Lee ,  Garrick Packard ,  Jingjing Zhao ,  Patrick Anthony Jokiel ,  Deborah Mortensen ,  Jennifer Riggs ,  Juan Antonio Gamboa ,  Maria Georges Beauchamps ,  Matthew Michael Kreilein ,  Mohit Atul Kothare ,  Sophie Perrin-Ninkovic ,  Philip Pye ,  William Wei-Hwa Leong ,  Jan Elsner

发明人： Roy L. Harris ,  John Sapienza ,  Graziella Shevlin ,  Patrick Papa ,  Branden Gingsee Lee ,  Garrick Packard ,  Jingjing Zhao ,  Patrick Anthony Jokiel ,  Deborah Mortensen ,  Jennifer Riggs ,  Juan Antonio Gamboa ,  Maria Georges Beauchamps ,  Matthew Michael Kreilein ,  Mohit Atul Kothare ,  Sophie Perrin-Ninkovic ,  Philip Pye ,  William Wei-Hwa Leong ,  Jan Elsner

IPC分类号： C07D487/04 ,  C07D498/14

CPC分类号： C07D471/04 ,  C07D241/20 ,  C07D487/04 ,  C07D498/14 ,  C07D519/00

摘要： Provided herein are methods to prepare Heteroaryl Compounds having the following structure: wherein R1-R4 are as defined herein. The Heteroaryl compounds are useful for treating or preventing cancer, inflammatory conditions, immunological conditions, neurodegenerative diseases, diabetes, obesity, neurological disorders, age-related diseases, or cardiovascular conditions.

摘要翻译： 本文提供了制备具有以下结构的杂芳基化合物的方法：其中R 1 -R 4如本文所定义。 杂芳基化合物可用于治疗或预防癌症，炎症状况，免疫学条件，神经变性疾病，糖尿病，肥胖症，神经障碍，年龄相关疾病或心血管疾病。

公开(公告)号：US08569494B2

公开(公告)日：2013-10-29

申请号：US12910920

申请日：2010-10-25

申请人： Roy L. Harris ,  John Sapienza ,  Graziella Shevlin ,  Patrick Papa ,  Branden Gingsee Lee ,  Garrick Packard ,  Jingjing Zhao ,  Patrick Anthony Jokiel ,  Deborah Mortensen ,  Jennifer Riggs ,  Juan Antonio Gamboa ,  Marie Georges Beauchamps ,  Matthew Michael Kreilein ,  Mohit Atul Kothare ,  Sophie Perrin-Ninkovic ,  Philip James Pye ,  William Wei-Hwa Leong ,  Jan Elsner ,  Anusuya Choudhury

发明人： Roy L. Harris ,  John Sapienza ,  Graziella Shevlin ,  Patrick Papa ,  Branden Gingsee Lee ,  Garrick Packard ,  Jingjing Zhao ,  Patrick Anthony Jokiel ,  Deborah Mortensen ,  Jennifer Riggs ,  Juan Antonio Gamboa ,  Marie Georges Beauchamps ,  Matthew Michael Kreilein ,  Mohit Atul Kothare ,  Sophie Perrin-Ninkovic ,  Philip James Pye ,  William Wei-Hwa Leong ,  Jan Elsner ,  Anusuya Choudhury

IPC分类号： C07D471/00

CPC分类号： C07D471/04 ,  C07D241/20 ,  C07D487/04 ,  C07D498/14 ,  C07D519/00

摘要： Provided herein are methods to prepare Heteroaryl Compounds having the following structure: wherein R1-R4 are as defined herein. The Heteroaryl compounds are useful for treating or preventing cancer, inflammatory conditions, immunological conditions, neurodegenerative diseases, diabetes, obesity, neurological disorders, age-related diseases, or cardiovascular conditions.