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公开(公告)号：US20190336619A1
公开(公告)日：2019-11-07
申请号：US16401265
申请日：2019-05-02
Applicant: Royal Melbourne Institute of Technology
Inventor： Amanda Anderson , Vipul Bansal , Jos Laurie Campbell , Rajesh Ramanathan , Ravi Shukla , Jyoti Arora
Abstract: A multimodal PET (positron emission tomography)/MRI (magnetic resonance imaging) contrast agent, a process of synthesizing said PET/MRI contrast agent, and a pharmaceutical formulation comprising said PET/MRI contrast agent are disclosed. The PET/MRI contrast agent comprises a magnetic signal generating core, and a coating portion formed at least partially over a surface of said magnetic signal generating core, wherein the coating portion comprises a plurality of layers, including an inner layer having a functionalized surface, and an outer layer in the form of a radionuclide electrolessly plated layer formed on said functionalized surface.
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Patent Agency Ranking
公开(公告)号：US11897785B2
公开(公告)日：2024-02-13
申请号：US17057626
申请日：2019-05-22
Applicant: Royal Melbourne Institute of Technology
Inventor： Vipul Bansal , Mandeep Singh , Rajesh Ramanathan , Amanda Anderson
CPC classification number: C01G49/0009 , A61K41/0052 , A61K49/1839 , A61K49/1851 , C01G49/06 , C01G49/08 , C01P2006/22 , C01P2006/42
Abstract: A method for preparing an aqueous dispersion of metal oxide particles is disclosed. The method comprises the step of performing phase transfer of a plurality of metal oxide particles capped with hydrophobic ligands on a surface there of by contacting the metal oxide particles with a combination of tertiary amine and water to form a biphasic mixture, and agitating said biphasic mixture to produce an aqueous dispersion of metal oxide particles capped with hydrophobic ligands and tertiary amine ligands on the surface thereof.
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公开(公告)号：US20230138790A1
公开(公告)日：2023-05-04
申请号：US17879351
申请日：2022-08-02
Applicant: Royal Melbourne Institute of Technology
Inventor： Amanda Anderson , Vipul Bansal , Jos Laurie Campbell , Rajesh Ramanathan , Ravi Shukla , Jyoti Arora
Abstract: A multimodal PET (positron emission tomography)/MRI (magnetic resonance imaging) contrast agent, a process of synthesizing said PET/MRI contrast agent, and a pharmaceutical formulation comprising said PET/MRI contrast agent are disclosed. The PET/MRI contrast agent comprises a magnetic signal generating core, and a coating portion formed at least partially over a surface of said magnetic signal generating core, wherein the coating portion comprises a plurality of layers, including an inner layer having a functionalized surface, and an outer layer in the form of a radionuclide electrolessly plated layer formed on said functionalized surface.
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公开(公告)号：US11267723B2
公开(公告)日：2022-03-08
申请号：US16333691
申请日：2017-09-08
Applicant: Royal Melbourne Institute of Technology
Inventor： Amanda Anderson , Vipul Bansal , Jos Laurie Campbell , Rajesh Ramanathan , Jyoti Arora , Ravi Shukla
IPC: C01G1/02 , C01G49/02 , C01G49/08 , B01D21/01 , H01F1/11 , A61K49/06 , A61K49/18 , B03C1/01 , B03D3/06 , C01B13/16
Abstract: A method of purifying a plurality of metal oxide particles produced from a synthesis process comprising the step of washing a plurality of metal oxide particles in a first solvent composition comprising of at least one aliphatic ether, and at least one flocculant. In one embodiment, the plurality of metal oxide particles are iron oxide particles produced from a thermal decomposition synthesis process between an iron-oleate complex and oleic acid in 1-octadecene, wherein the first solvent composition comprises a 1:1 (vol/vol) ratio of an aliphatic ether in the form of diethyl ether and a flocculant in the form of methanol. The washed iron oxide particles are further washed in a second solvent composition comprising a 1:1 (vol/vol) ratio of hexane and ethanol, and then finally dispersed in hexane. The resulting iron oxide particles find use as a contrast agent for magnetic resonance imaging (MRI) or as magnetic particles in magnetic separation, magnetism-directed targeting or magnetism-induced heating.
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公开(公告)号：US20210163311A1
公开(公告)日：2021-06-03
申请号：US17057626
申请日：2019-05-22
Applicant: Royal Melbourne Institute of Technology
Inventor： Vipul Bansal , Mandeep Singh , Rajesh Ramanathan , Amanda Anderson
Abstract: A method for preparing an aqueous dispersion of metal oxide particles is disclosed. The method comprises the step of performing phase transfer of a plurality of metal oxide particles capped with hydrophobic ligands on a surface there of by contacting the metal oxide particles with a combination of tertiary amine and water to form a biphasic mixture, and agitating said biphasic mixture to produce an aqueous dispersion of metal oxide particles capped with hydrophobic ligands and tertiary amine ligands on the surface thereof.
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公开(公告)号：US20190225491A1
公开(公告)日：2019-07-25
申请号：US16333691
申请日：2017-09-08
Applicant: Royal Melbourne Institute of Technology
Inventor： Amanda Anderson , Vipul Bansal , Jos Laurie Campbell , Rajesh Ramanathan , Jyoti Arora , Ravi Shukla
Abstract: A method of purifying a plurality of metal oxide particles produced from a synthesis process is disclosed. The method comprises the step of washing a plurality of metal oxide particles in a first solvent composition comprising of at least one aliphatic ether, and at least one flocculant. In one embodiment, the plurality of metal oxide particles are iron oxide particles produced from a thermal decomposition synthesis process between an iron-oleate complex and oleic acid in 1-octadecene, wherein the first solvent composition comprises a 1:1 (vol/vol) ratio of an aliphatic ether in the form of diethyl ether and a flocculant in the form of methanol. The washed iron oxide particles are further washed in a second solvent composition comprising a 1:1 (vol/vol) ratio of hexane and ethanol, and then finally dispersed in hexane. The resulting iron oxide particles find use as a contrast agent for magnetic resonance imaging (MRI) or as magnetic particles in magnetic separation, magnetism-directed targeting or magnetism-induced heating.
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