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29 条记录 (耗时 0.026 秒)

    Elimination of contrast agent concentration dependency in MRI
    1.
    发明授权
    Elimination of contrast agent concentration dependency in MRI 有权
    消除MRI中造影剂浓度依赖性

    公开(公告)号：US08463358B2

    公开(公告)日：2013-06-11

    申请号：US12303453

    申请日：2007-06-08

    申请人： Rudolf Mathias Johannes Nicolaas Lamerichs ,  Rene Theodorus Wegh ,  Jeroen Alphons Pikkemaat ,  Holger Gruell

    发明人： Rudolf Mathias Johannes Nicolaas Lamerichs ,  Rene Theodorus Wegh ,  Jeroen Alphons Pikkemaat ,  Holger Gruell

    IPC分类号： A61B5/05

    CPC分类号： A61K49/0002 ,  A61K49/06 ,  G01R33/5601

    摘要： A method for MRI imaging to obtain information about a local physiochemical parameter after administration to a patient of a contrast agent including at least one non-responsive contrast enhancing entity that does not occur naturally in a human body and at least one responsive contrast enhancing entity attached to or mixed with the non-responsive contrast enhancing entity. By using such non-responsive contrast enhancing entities, a value for the physicochemical parameter can be obtained by acquiring only three images, providing a method which will be easier to apply in a clinical routine, since it will be faster and less sensitive to motion or flow artifacts.

    摘要翻译： 一种用于MRI成像的方法，用于在给予造影剂的患者之后获得关于局部生理化学参数的信息，所述造影剂包括至少一个在人体内不天然存在的至少一个非反应性对比增强实体和至少一个响应性对比增强实体 与无反应对比度增强实体混合或混合。 通过使用这种无反应的对比度增强实体，可以通过仅获取三个图像来获得物理化学参数的值，提供将更容易应用于临床程序中的方法，因为它将对运动更快和更不敏感， 流动人造物。

    ELIMINATION OF CONTRAST AGENT CONCENTRATION DEPENDENCY IN MRI
    2.
    发明申请
    ELIMINATION OF CONTRAST AGENT CONCENTRATION DEPENDENCY IN MRI 有权
    消除MRI中的对比剂浓度依赖性

    公开(公告)号：US20090196830A1

    公开(公告)日：2009-08-06

    申请号：US12303453

    申请日：2007-06-08

    申请人： Rudolf Mathias Johannes Nicolaas Lamerichs ,  Rene Theodorus Wegh ,  Jeroen Alphons Pikkemaat ,  Holger Gruell

    发明人： Rudolf Mathias Johannes Nicolaas Lamerichs ,  Rene Theodorus Wegh ,  Jeroen Alphons Pikkemaat ,  Holger Gruell

    IPC分类号： A61K49/06

    CPC分类号： A61K49/0002 ,  A61K49/06 ,  G01R33/5601

    摘要： The present invention relates to a method for MRI imaging to obtain information about a local physiochemical parameter after administration to a patient of a contrast agent comprising at least one non-responsive contrast enhancing entity that does not occur naturally in a human body and at least one responsive contrast enhancing entity attached to or mixed with the non-responsive contrast enhancing entity. By using such non-responsive contrast enhancing entities, a value for the physicochemical parameter can be obtained by acquiring only three images through which the method according to the present invention will be easier to apply in clinical routine since it will be faster and less sensitive to motion or flow artefacts.

    摘要翻译： 本发明涉及一种用于MRI成像的方法，用于在给予造影剂的患者之后获得关于局部生理化学参数的信息，所述造影剂包括至少一个在人体内不自然发生的至少一个非反应性对比增强实体，以及至少一个 响应对比度增强实体附加于非混响对比度增强实体或与非响应对比增强实体混合。 通过使用这种无反应的对比度增强实体，可以通过仅获取三个图像来获得物理化学参数的值，通过该三个图像，根据本发明的方法将更容易应用于临床常规中，因为它将更快和更不敏感 运动或流动文物。

    Distinguishing bound and unbound contrast agents using magnetic resonance
    4.
    发明授权
    Distinguishing bound and unbound contrast agents using magnetic resonance 失效
    使用磁共振区分绑定和未结合的造影剂

    公开(公告)号：US07667460B2

    公开(公告)日：2010-02-23

    申请号：US12094270

    申请日：2006-11-22

    申请人： Rudolf Mathias Johannes Nicolaas Lamerichs ,  Rene Theodorus Wegh ,  Jeroen Alphons Pikkemaat ,  Holger Gruell

    发明人： Rudolf Mathias Johannes Nicolaas Lamerichs ,  Rene Theodorus Wegh ,  Jeroen Alphons Pikkemaat ,  Holger Gruell

    IPC分类号： G01V3/00

    CPC分类号： G01R33/281 ,  G01R33/5601 ,  G01R33/56341

    摘要： Magnetic resonance monitoring of a target (30) uses the detected magnetic resonance to determine movement such as diffusion of contrast agent relative to the object, and uses the movement to discriminate (50, 60) a part of the contrast agent which is bound to the target, from the rest of the contrast agent. The need for clearing agents can be avoided or reduced, and hence imaging is instantaneous. A “stationary spin map” of the object can be formed by comparing the movements in the different directions, and determining if the differences between them are less than a given threshold. Determining isotropic movement in this way for a number of locations on the object allows the map to be generated.

    摘要翻译： 目标（30）的磁共振监测使用检测到的磁共振来确定造影剂相对于物体的扩散的运动，并且使用该运动来区分（50,60）一部分与 目标，从其余的造影剂。 可以避免或减少对清除剂的需要，因此成像是瞬时的。 可以通过比较不同方向的运动并确定它们之间的差异是否小于给定的阈值来形成物体的“固定自旋图”。 以这种方式确定对象上多个位置的各向同性运动允许生成地图。

    Distinguishing Bound and Unbound Contrast Agents Using Magnetic Resonance
    5.
    发明申请
    Distinguishing Bound and Unbound Contrast Agents Using Magnetic Resonance 失效
    使用磁共振识别绑定和未绑定的对比剂

    公开(公告)号：US20080258726A1

    公开(公告)日：2008-10-23

    申请号：US12094270

    申请日：2006-11-22

    申请人： Rudolf Mathias Johannes Nicolaas Lamerichs ,  Rene Theodorus Wegh ,  Jeroen Alphons Pikkemaat ,  Holger Gruell

    发明人： Rudolf Mathias Johannes Nicolaas Lamerichs ,  Rene Theodorus Wegh ,  Jeroen Alphons Pikkemaat ,  Holger Gruell

    IPC分类号： G01R33/563

    CPC分类号： G01R33/281 ,  G01R33/5601 ,  G01R33/56341

    摘要： Magnetic resonance monitoring of a target (30) uses the detected magnetic resonance to determine movement such as diffusion of contrast agent relative to the object, and uses the movement to discriminate (50, 60) a part of the contrast agent which is bound to the target, from the rest of the contrast agent. The need for clearing agents can be avoided or reduced, and hence imaging is instantaneous. A “stationary spin map” of the object can be formed by comparing the movements in the different directions, and determining if the differences between them are less than a given threshold. Determining isotropic movement in this way for a number of locations on the object allows the map to be generated.

    摘要翻译： 目标（30）的磁共振监测使用检测到的磁共振来确定造影剂相对于物体的扩散的运动，并且使用该运动来区分（50,60）一部分与 目标，从其余的造影剂。 可以避免或减少对清除剂的需要，因此成像是瞬时的。 可以通过比较不同方向的运动并确定它们之间的差异是否小于给定的阈值来形成物体的“固定自旋图”。 以这种方式确定对象上多个位置的各向同性运动允许生成地图。

    MR IMAGING WITH CEST CONTRAST ENHANCEMENT
    7.
    发明申请
    MR IMAGING WITH CEST CONTRAST ENHANCEMENT 审中-公开
    成像与CEST对比增强

    公开(公告)号：US20110288402A1

    公开(公告)日：2011-11-24

    申请号：US13139518

    申请日：2009-12-15

    申请人： Jeroen Alphons Pikkemaat ,  Sander Langereis ,  Holger Gruell ,  Dirk Burdinski ,  Rudolf Mathias Johannes Nicolaas Lamerichs ,  Jochen Keupp

    发明人： Jeroen Alphons Pikkemaat ,  Sander Langereis ,  Holger Gruell ,  Dirk Burdinski ,  Rudolf Mathias Johannes Nicolaas Lamerichs ,  Jochen Keupp

    IPC分类号： A61B5/055

    CPC分类号： G01R33/5601 ,  G01R33/5616

    摘要： The invention relates to a method of MR imaging of at least a portion of a body of a patient placed in an examination volume of an MR device. The object of the invention is to improve CEST contrast enhanced imaging. The method of the invention comprises the following steps: a) saturation of nuclear magnetization of exchangeable protons of a CEST contrast agent administered to the patient by subjecting the portion of the body to at least one frequency-selective saturation RF pulse matched to the MR frequency of exchangeable protons of the CEST contrast agent, wherein the saturation period, i.e. the duration of the frequency-selective saturation RF pulse, is shorter than the time required for saturation to build up a full CEST contrast enhancement effect when starting from zero saturation; b) generating at least one MR signal of water protons of the body by subjecting the portion of the body to an MR imaging sequence comprising at least one RF pulse and switched magnetic field gradients; c) acquiring sampling the at least one MR signal from the body; d) repeating steps a) to c) a number of times under variation of parameters of the MR imaging sequence, wherein MR signals are acquired and sampled during a saturation build-up period, i.e. before a steady state of the CEST effect is achieved; e) reconstructing a proton-density weighted, CEST contrast-enhanced MR image from the acquired and sampled MR signals.

    摘要翻译： 本发明涉及放置在MR装置检查体积中的患者身体的至少一部分的MR成像方法。 本发明的目的是改善CEST对比度增强成像。 本发明的方法包括以下步骤：a）通过使身体的一部分经受与MR频率匹配的至少一个频率选择性饱和RF脉冲，使给予患者的CEST造影剂的可交换质子的核磁化饱和 的CEST造影剂的可交换质子，其中饱和周期，即频率选择性饱和RF脉冲的持续时间比从零饱和开始时建立饱和CEST对比度增强效果所需的时间短; b）通过使身体的一部分经受包括至少一个RF脉冲和切换的磁场梯度的MR成像序列来产生身体的水质子的至少一个MR信号; c）从身体采集至少一个MR信号; d）在MR成像序列的参数变化下重复步骤a）至c）多次，其中在饱和建立期间，即在实现CEST效应的稳定状态之前获取和采样MR信号; e）从获取和采样的MR信号重构质子密度加权的CEST对比度增强的MR图像。

    Responsive MRI contrast agents
    9.
    发明授权
    Responsive MRI contrast agents 有权
    响应性MRI造影剂

    公开(公告)号：US08734761B2

    公开(公告)日：2014-05-27

    申请号：US11912694

    申请日：2006-04-21

    申请人： Nicolaas Petrus Willard ,  Rene Theodorus Wegh ,  Jeroen Alphons Pikkemaat ,  Holger Gruell

    发明人： Nicolaas Petrus Willard ,  Rene Theodorus Wegh ,  Jeroen Alphons Pikkemaat ,  Holger Gruell

    IPC分类号： A61B5/055

    CPC分类号： A61K49/124 ,  A61K49/1812 ,  A61K49/1821

    摘要： The invention provides MRI contrast agents which provide a high sensitivity and which have an optimised body retention time. These agents enable the mapping of the local pH, temperature, oxygen concentration or other metabolites in a patient's body by the use of Chemical Exchange Saturation Transfer (CEST). Particularly pH and temperature mapping are useful for the detection of small cancer lesions and localized inflammation respectively.

    摘要翻译： 本发明提供了提供高灵敏度并且具有优化的身体保留时间的MRI造影剂。 这些试剂可以通过使用化学交换饱和转移（CEST）来测定患者体内的局部pH，温度，氧浓度或其他代谢物。 特别是pH和温度映射可用于分别检测小癌病变和局部炎症。

    Perfluoro Compounds For Use In Imaging
    10.
    发明申请
    Perfluoro Compounds For Use In Imaging 审中-公开
    全氟化合物用于成像

    公开(公告)号：US20120128589A1

    公开(公告)日：2012-05-24

    申请号：US13387748

    申请日：2010-07-21

    申请人： Muhammed Yildirim ,  Holger Gruell ,  Rudolf Mathias Johannes Nicolaas Lamerichs

    发明人： Muhammed Yildirim ,  Holger Gruell ,  Rudolf Mathias Johannes Nicolaas Lamerichs

    IPC分类号： A61K49/10 ,  C07C22/00 ,  A61K51/04 ,  B82Y25/00 ,  B82Y5/00

    CPC分类号： A61K49/1809 ,  A61K49/10 ,  A61K49/1881 ,  B82Y5/00

    摘要： Described is the use of perfluoro-t-butyl cyclohexane in a contrast agent for molecular imaging, notably F MRI. Particularly, the perfluoro-t-butyl cyclohexane is present in the form of an aqueous emulsion of nanoparticles comprising the perfluoro compound as a core, and an emulsifying agent, such as a phospholipid, as a shell. The shell can be functionalized with other moieties that play a role in imaging, notably ligands for targeted binding and/or contrast agents or labels with a view to other imaging modalities. The latter particularly refers to 1H MRI contrast agents as well as radiolabels for SPECT.

    摘要翻译： 描述了在造影剂中使用全氟叔丁基环己烷进行分子成像，特别是F MRI。 特别地，全氟叔丁基环己烷以包含全氟化合物为核心的纳米颗粒的水性乳液和乳化剂如磷脂作为壳体的形式存在。 壳可以与在成像中起作用的其它部分官能化，特别是用于靶向结合和/或造影剂或标签的配体，以期考虑其它成像方式。 后者特别指的是1H MRI造影剂以及用于SPECT的放射性标记。