公开(公告)号：US20170143836A1

公开(公告)日：2017-05-25

申请号：US15365088

申请日：2016-11-30

申请人： Rutgers, The State University of New Jersey ,  Lehigh University

发明人： Jeffrey D. Laskin ,  Diane E. Heck ,  Mou-Tuan Huang ,  Karine Fabio ,  Jeffrey C. Lacey ,  Sherri C. Young ,  Pramod Mohanta ,  Christophe Gullion ,  Ned D. Heindel

IPC分类号： A61K31/695 ,  C07F7/08 ,  C07D209/28 ,  A61K31/192 ,  A61K31/405 ,  A61K9/00 ,  C07C69/96 ,  C07C229/42

CPC分类号： C07F7/0812 ,  A61K9/0014 ,  A61K31/19 ,  A61K31/192 ,  A61K31/196 ,  A61K31/405 ,  A61K47/54 ,  A61K47/55 ,  C07C69/96 ,  C07C229/42 ,  C07C2602/10 ,  C07D209/28 ,  C07F7/081

摘要： A new family of therapeutics which provides a controlled-release delivery platform for non-steroidal anti-inflammatory agents on an ester or an ester-carbonate backbone is disclosed herein. These agents are reversible inhibitors of acetylcholinesterase and are thus useful for clinical conditions benefiting from inflammation suppression and cholinergic intervention. These compounds are of the general formula wherein n=0, 1; X═C, Si, and N+ and NSAID=ibuprofen, naproxen, indomethacin and diclofenac. Other embodiments are also disclosed.

公开(公告)号：US10570161B2

公开(公告)日：2020-02-25

申请号：US15365088

申请日：2016-11-30

申请人： Rutgers, The State University of New Jersey ,  Lehigh University

发明人： Jeffrey D. Laskin ,  Diane E. Heck ,  Mou-Tuan Huang ,  Karine Fabio ,  Carl J. Lacey ,  Sherri C. Young ,  Pramod Mohanta ,  Christophe Guillon ,  Ned D. Heindel

IPC分类号： C07F7/08 ,  A61K31/405 ,  A61K31/196 ,  A61K31/19 ,  A61K47/55 ,  A61K47/54 ,  A61K9/00 ,  A61K31/192 ,  C07C69/96 ,  C07C229/42 ,  C07C209/28 ,  C07D209/28

摘要： A new family of therapeutics which provides a controlled-release delivery platform for non-steroidal anti-inflammatory agents on an ester or an ester-carbonate backbone is disclosed herein. These agents are reversible inhibitors of acetylcholinesterase and are thus useful for clinical conditions benefiting from inflammation suppression and cholinergic intervention. These compounds are of the general formula wherein n=0, 1; X=C, Si, and N+ and NSAID=ibuprofen, naproxen, indomethacin and diclofenac. Other embodiments are also disclosed.