公开(公告)号：US20120309034A1

公开(公告)日：2012-12-06

申请号：US13577530

申请日：2011-02-07

申请人： Ryo Kojima ,  Kenta Noda ,  Masanori Seimiya ,  Kazuyuki Sogawa ,  Fumio Nomura

发明人： Ryo Kojima ,  Kenta Noda ,  Masanori Seimiya ,  Kazuyuki Sogawa ,  Fumio Nomura

IPC分类号： G01N21/59 ,  G01N33/574 ,  G01N33/566

CPC分类号： G01N33/57484 ,  G01N33/564 ,  G01N2333/922

摘要： A reaginic antibody of Ku86 and a substance capable of binding with the autoantibody of Ku86 are acted on a complex of Ku86 and the autoantibody thereof in a subject. Said complex can be measured by measuring the obtained immune complex of the aforementioned complex, reaginic antibody, and substance capable of binding with the autoantibody of Ku86. As a consequence, it is possible to determine whether the cancer is a primary hepatoma, colon cancer, stomach cancer, pancreatic cancer, breast cancer, lung cancer, or an esophageal cancer.

摘要翻译： Ku86的反应性抗体和能够与Ku86的自身抗体结合的物质作用于受试者中Ku86和其自身抗体的复合物。 所述复合物可以通过测量获得的上述复合物，反应性抗体和能够与Ku86自身抗体结合的物质的免疫复合物来测量。 因此，可以确定癌症是原发性肝癌，结肠癌，胃癌，胰腺癌，乳腺癌，肺癌或食管癌。

公开(公告)号：US20120282638A1

公开(公告)日：2012-11-08

申请号：US13521084

申请日：2011-01-18

申请人： Ryo Kojima ,  Kenta Noda ,  Masanori Seimiya ,  Kazuyuki Sogawa ,  Fumio Nomura

发明人： Ryo Kojima ,  Kenta Noda ,  Masanori Seimiya ,  Kazuyuki Sogawa ,  Fumio Nomura

IPC分类号： G01N33/574 ,  C07K16/18 ,  C07K14/46

CPC分类号： G01N33/6854 ,  G01N33/564 ,  G01N33/57438 ,  G01N33/57484 ,  G01N2333/47 ,  G01N2333/90

摘要： An autoantibody against Ku86 can be measured by reacting the autoantibody contained in a sample with a Ku86 antigen (which serves as a reagent) to produce an immune complex of the autoantibody and the Ku86 antigen and measuring the immune complex using a labeled anti-human immunoglobulin antibody. The measurement of the autoantibody enables the determination of primary hepatocellular carcinoma.

摘要翻译： 可以通过使样品中包含的自身抗体与Ku86抗原（其用作试剂）反应以产生自身抗体和Ku86抗原的免疫复合物并使用标记的抗人免疫球蛋白测量免疫复合物来测量针对Ku86的自身抗体 抗体。 自身抗体的测定能够确定原发性肝细胞癌。