公开(公告)号：US4013639A

公开(公告)日：1977-03-22

申请号：US382120

申请日：1973-07-24

申请人： Ryoichi Kitamura ,  Eiichi Kitamura ,  Tetsuo Kitamura ,  Tameo Kitamura

发明人： Ryoichi Kitamura ,  Eiichi Kitamura ,  Tetsuo Kitamura ,  Tameo Kitamura

IPC分类号： C07D223/22 ,  C07D223/28

CPC分类号： C07D223/22

摘要： Iminodibenzyl derivatives of the formula: ##SPC1##Wherein R and R.sup.1 each represent hydrogen, halogen, amino, sulfamoyl, lower alkyl, lower alkoxy or lower alkanoyl, provided that R and R.sup.1 can not both be hydrogen and when R and R.sup.1 are the same, they are located at positions asymmetric to each other, are produced in high purity and yield by a series of reactions which proceed through novel 2,2'-dinitrostilbene or 2,2'-diaminostilbene and 2,2'-diaminodibenzyl derivatives. The reaction sequence involves condensation, reduction and ring-closure reactions to give asymmetric as well as symmetric iminodibenzyl derivatives. The resulting iminodibenzyl derivatives may be converted to useful pharmaceutical compounds having anti-depressant, analgesic or anti-allergic properties.