公开(公告)号：US09162316B2

公开(公告)日：2015-10-20

申请号：US13812074

申请日：2011-07-20

申请人： Ryuichi Narita ,  Takashi Hanioka ,  Tadahiro Kimura ,  Masahiro Kimura ,  Masao Shiota

发明人： Ryuichi Narita ,  Takashi Hanioka ,  Tadahiro Kimura ,  Masahiro Kimura ,  Masao Shiota

IPC分类号： B23K15/00

CPC分类号： B23K15/0046 ,  B23K15/00 ,  B23K15/0053 ,  B23K15/006

摘要： An electron beam welding method capable of restoring toughness even when high heat input welding is performed. The electron beam welding method comprises: forming a first weld bead (3) so as to include a groove (2) provided at the butt portions of two base materials (1), and forming a second weld bead (4) and a third weld bead (5) having a narrower width than the first weld bead (3), at predetermined positions displaced from the groove (2) and centered symmetrically about the butt portions so as to include a portion of the first weld bead (3), using a lower heat input than that used during formation of the first weld bead (3).

摘要翻译： 即使进行高热输入焊接也能够恢复韧性的电子束焊接方法。 电子束焊接方法包括：形成第一焊道（3），以包括设置在两个基材（1）的对接部分处的凹槽（2），并形成第二焊道（4）和第三焊缝 具有比第一焊道（3）窄的宽度的胎圈（5），在从凹槽（2）移位并围绕对接部分对称地定中心的预定位置处，以便包括第一焊道（3）的一部分，使用 比在第一焊道（3）的形成期间使用的热输入更低的热输入。

公开(公告)号：US20130126484A1

公开(公告)日：2013-05-23

申请号：US13812074

申请日：2011-07-20

申请人： Ryuichi Narita ,  Takashi Hanioka ,  Tadahiro Kimura ,  Masahiro Kimura ,  Masao Shiota

发明人： Ryuichi Narita ,  Takashi Hanioka ,  Tadahiro Kimura ,  Masahiro Kimura ,  Masao Shiota

IPC分类号： B23K15/00

CPC分类号： B23K15/0046 ,  B23K15/00 ,  B23K15/0053 ,  B23K15/006

摘要： An electron beam welding method capable of restoring toughness even when high heat input welding is performed. The electron beam welding method comprises: forming a first weld bead (3) so as to include a groove (2) provided at the butt portions of two base materials (1), and forming a second weld bead (4) and a third weld bead (5) having a narrower width than the first weld bead (3), at predetermined positions displaced from the groove (2) and centered symmetrically about the butt portions so as to include a portion of the first weld bead (3), using a lower heat input than that used during formation of the first weld bead (3).

摘要翻译： 即使进行高热输入焊接也能够恢复韧性的电子束焊接方法。 电子束焊接方法包括：形成第一焊道（3），以包括设置在两个基材（1）的对接部分处的凹槽（2），并形成第二焊道（4）和第三焊缝 具有比第一焊道（3）窄的宽度的胎圈（5），在从凹槽（2）移位并围绕对接部分对称地定中心的预定位置处，以便包括第一焊道（3）的一部分，使用 比在第一焊道（3）的形成期间使用的热输入更低的热输入。

公开(公告)号：US06461593B1

公开(公告)日：2002-10-08

申请号：US07838604

申请日：1992-02-19

申请人： Takashi Hanioka ,  Judson T. McRee ,  Karl Folkers

发明人： Takashi Hanioka ,  Judson T. McRee ,  Karl Folkers

IPC分类号： A61K716

CPC分类号： A61K31/122 ,  A61K8/355 ,  A61K9/0063 ,  A61Q11/00

摘要： The presence of diverse microorganisms in the gingiva of patients having periodontal disease is very well known to be deleterious to gingival health, and particularly to facilitate the appearance and development of dental cavities. Such microorganisms are always associated with periodontal disease, and if such microorganisms remain unchecked or uncontrolled, extraction of teeth are likely to occur. In the past, the presence of microorganisms in the gingiva of patients with periodontal disease has been periodically and erratically treated with anti-microbial agents, including antibiotics. For anti-microbial agents and antibiotics to be effective in the gingiva, such agents and antibiotics must come into direct contact with microorganisms, and such contact is known to be incomplete, partly because there may be barriers of fluid and tissue which prevent direct contact between the agents and antibiotics with the microorganisms. Also, such agents can be inactive for certain microorganisms and even when there is activity, such microorganisms can become metabolically resistant to the agents and antibiotics. A more effective way to reduce and to control microorganisms in the gingiva of patients with periodontal disease is to increase the efficacy of the immune system of the host. Coenzyme Q10 (CoQ10) has been known to increase the immune system, but previously it was unknown that CoQ10 could be a very effective mechanism to reduce and to eliminate microorganisms in the gingiva of patients with periodontal disease.

摘要翻译： 具有牙周病的患者牙龈中多种微生物的存在是众所周知的，对牙龈健康有害，特别是促进牙腔的外观和发育。 这样的微生物总是与牙周病有关，如果这种微生物保持不受控制或不受控制，则可能会出现牙齿的提取。在过去，牙周病患者的牙龈中的微生物的存在已经定期地和不定期地用抗 - 微生物剂，包括抗生素。 为了使抗微生物剂和抗生素在牙龈中有效，这种药剂和抗生素必须与微生物直接接触，这种接触已知是不完全的，部分原因是可能存在妨碍液体和组织之间直接接触的障碍 代理商和抗生素与微生物。 此外，这些药剂对于某些微生物也是无活性的，甚至当有活性时，这样的微生物可以代谢对药物和抗生素的抗性。减少和控制牙周病患者牙龈中微生物的更有效的方法是增加 宿主免疫系统的功效。 已知辅酶Q10（CoQ10）可增加免疫系统，但以前不知道CoQ10可能是减少和消除牙周病患者牙龈中微生物的非常有效的机制。