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    Sequential drug delivery systems
    1.
    发明授权
    Sequential drug delivery systems 有权
    顺序药物递送系统

    公开(公告)号：US07670617B2

    公开(公告)日：2010-03-02

    申请号：US10936185

    申请日：2004-09-08

    申请人： S. Indiran Pather ,  John Hontz ,  John M. Siebert

    发明人： S. Indiran Pather ,  John Hontz ,  John M. Siebert

    IPC分类号： A61F9/02

    CPC分类号： A61K9/0034 ,  A61K9/025 ,  A61K9/2054 ,  A61K9/2081 ,  A61K31/48

    摘要： The invention relates to methods and composition for improving absorption and dissolution of active ingredients of drugs. The invention provides a method of administration of an active ingredient to a mammal through a transmucosal route that includes delivering the active ingredient to a desired site in a body of the mammal, and, sequentially, at the desired site, promoting dissolution and absorption of the active ingredient. In a preferred embodiment, the pH of the localized environment of the active ingredient is sequentially modified to promote dissolution and absorption.

    摘要翻译： 本发明涉及用于改善药物活性成分吸收和溶解的方法和组合物。 本发明提供了通过经粘膜途径向哺乳动物施用活性成分的方法，其包括将活性成分递送至哺乳动物体内的期望部位，并且依次在所需位点促进溶解和吸收 有效成分。 在优选的实施方案中，活性成分的局部环境的pH被依次修饰以促进溶解和吸收。

    Effervescent drug delivery system for oral administration
    3.
    发明授权
    Effervescent drug delivery system for oral administration 有权
    用于口服给药的泡腾药物递送系统

    公开(公告)号：US06764696B2

    公开(公告)日：2004-07-20

    申请号：US10346829

    申请日：2003-03-18

    申请人： S. Indiran Pather ,  Joseph R. Robinson ,  Jonathan D. Eichman ,  Rajendra K. Khankari ,  John Hontz ,  Sangeeta V. Gupte

    发明人： S. Indiran Pather ,  Joseph R. Robinson ,  Jonathan D. Eichman ,  Rajendra K. Khankari ,  John Hontz ,  Sangeeta V. Gupte

    IPC分类号： A61K924

    CPC分类号： A61K9/2886 ,  A61K9/0007 ,  A61K9/2072 ,  A61K9/2866 ,  A61K9/5084 ,  Y10S514/96

    摘要： The pharmaceutical compositions of the present invention comprise orally administerable dosage forms that use effervescence as a penetration enhancer for drugs known, or suspected, of having poor bioavailability. Effervescence can occur in the stomach, once the tablet or other dosage form is ingested. In addition to effervescence in the stomach, or as alternative technique, by the use of appropriate coatings and other techniques, the effervescence can occur in other parts of the gastrointestinal tract, including, but not limited to, the esophagus, duodenum, and colon. The site of effervescence and drug release is chosen to correspond with the segment of the gastrointestinal tract displaying maximal absorption of the formulated drug, or to gain some other therapeutic advantage.

    摘要翻译： 本发明的药物组合物包含口服给药剂型，其使用泡腾作为已知或怀疑具有差的生物利用度的药物的渗透增强剂。 一旦片剂或其他剂型被摄取，起泡可能发生在胃中。 除了在胃中起泡或作为替代技术，通过使用适当的包衣和其它技术，泡腾可以发生在胃肠道的其它部分，包括但不限于食道，十二指肠和结肠。 选择泡腾和药物释放的部位以与显示配制药物的最大吸收的胃肠道的部分相对应，或获得一些其他治疗优势。

    Emulsions as solid dosage forms for oral administration
    4.
    发明授权
    Emulsions as solid dosage forms for oral administration 有权
    乳剂作为口服给药的固体剂型

    公开(公告)号：US06692771B2

    公开(公告)日：2004-02-17

    申请号：US09792659

    申请日：2001-02-23

    申请人： S. Indiran Pather ,  Sangeeta V. Gupte ,  Rajendra K. Khankari ,  John Hontz ,  Ramya Kumbale

    发明人： S. Indiran Pather ,  Sangeeta V. Gupte ,  Rajendra K. Khankari ,  John Hontz ,  Ramya Kumbale

    IPC分类号： A61K916

    CPC分类号： A61K9/143

    摘要： Novel emulsion compositions which improve the rate and/or extent of absorption of drugs are disclosed. The novel emulsion compositions of the present invention include drug-containing emulsions adsorbed onto solid particles which may be further formulated into solid dosage forms, methods of preparing such emulsion compositions and their uses thereof. The emulsion compositions and their dosage forms improve the drug-load and the bioavailability of a wide range of drugs including drugs that are known or suspected of having poor bioavailability by the utilization of several different mechanisms.

    摘要翻译： 公开了提高药物吸收速率和/或程度的新型乳液组合物。 本发明的新型乳液组合物包括吸附在固体颗粒上的含药乳液，其可以进一步配制成固体剂型，制备这种乳液组合物的方法及其应用。 乳剂组合物及其剂型通过利用几种不同的机制改善了广泛范围的药物，包括已知或怀疑具有差的生物利用度的药物的药物负载和生物利用度。

    Effervescent drug delivery system for oral administration
    10.
    发明授权
    Effervescent drug delivery system for oral administration 有权
    用于口服给药的泡腾药物递送系统

    公开(公告)号：US06350470B1

    公开(公告)日：2002-02-26

    申请号：US09302105

    申请日：1999-04-29

    申请人： S. Indiran Pather ,  Joseph R. Robinson ,  Jonathan D. Eichman ,  Rajendra K. Khankari ,  John Hontz ,  Sangeeta V. Gupte

    发明人： S. Indiran Pather ,  Joseph R. Robinson ,  Jonathan D. Eichman ,  Rajendra K. Khankari ,  John Hontz ,  Sangeeta V. Gupte

    IPC分类号： A61K924

    CPC分类号： A61K9/2886 ,  A61K9/0007 ,  A61K9/2072 ,  A61K9/2866 ,  A61K9/5084 ,  Y10S514/96

    摘要： The pharmaceutical compositions of the present invention comprise orally administerable dosage forms that use effervescence as a penetration enhancer for drugs known, or suspected, of having poor bioavailability. Effervescence can occur in the stomach, once the tablet or other dosage form is ingested. In addition to effervescence in the stomach, or as alternative technique, by the use of appropriate coatings and other techniques, the effervescence can occur in other parts of the gastrointestinal tract, including, but not limited to, the esophagus, duodenum, and colon. The site of effervescence and drug release is chosen to correspond with the segment of the gastrointestinal tract displaying maximal absorption of the formulated drug, or to gain some other therapeutic advantage.

    摘要翻译： 本发明的药物组合物包含口服给药剂型，其使用泡腾作为已知或怀疑具有差的生物利用度的药物的渗透增强剂。 一旦片剂或其他剂型被摄取，起泡可能发生在胃中。 除了在胃中起泡或作为替代技术，通过使用适当的包衣和其它技术，泡腾可以发生在胃肠道的其它部分，包括但不限于食道，十二指肠和结肠。 选择泡腾和药物释放的部位以与显示配制药物的最大吸收的胃肠道的部分相对应，或获得一些其他治疗优势。