公开(公告)号：US20170233489A1

公开(公告)日：2017-08-17

申请号：US15313923

申请日：2014-05-26

Applicant: Samsung Electronics Co., Ltd.

Inventor： Seon Hui SHIM ,  Jung Wook LEE

IPC: C07K16/32 ,  C07K16/28

CPC classification number: C07K16/32 ,  A61K2039/507 ,  C07K16/2863 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/76

Abstract: A composition for combination therapy for preventing and/or treating a cancer, and a composition for combination therapy for inhibiting metastasis and/or angiogenesis, including an anti-c-Met antibody and an anti-HER2 antibody; and a method of preventing and/or treating a cancer and a method of inhibiting metastasis and/or angiogenesis, including co-administering an anti-c-Met antibody and an anti-HER2 antibody, are provided.

公开(公告)号：US20150192588A1

公开(公告)日：2015-07-09

申请号：US14591787

申请日：2015-01-07

Applicant: SAMSUNG ELECTRONICS CO., LTD.

Inventor： Soo Yeon JUNG ,  Seon Hui SHIM ,  Yun Jeong SONG ,  Hyeon-seok YOO

IPC: G01N33/574 ,  C07K16/40

CPC classification number: G01N33/57488 ,  A61K2039/505 ,  C07K16/40 ,  C07K2317/24 ,  C07K2317/53 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/76 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/158 ,  G01N33/57419 ,  G01N33/57423 ,  G01N33/57446 ,  G01N2333/495 ,  G01N2333/5421 ,  G01N2333/99 ,  G01N2800/52

Abstract: A biomarker for predicting and/or monitoring the efficacy of a c-Met inhibitor; a composition for predicting and/or monitoring the efficacy of a c-Met inhibitor, comprising a material detecting the biomarker; a composition for selecting a subject suitable for the application of a c-Met inhibitor, comprising a material detecting the biomarker; a method for predicting and/or monitoring the efficacy of a c-Met inhibitor using the biomarker; a method for selecting a subject suitable for the application of a c-Met inhibitor using the biomarker; and a method for preventing and/or treating cancer comprising administering a c-Met inhibitor to the selected subject.

Abstract translation: 用于预测和/或监测c-Met抑制剂功效的生物标志物; 用于预测和/或监测c-Met抑制剂的功效的组合物，其包含检测生物标志物的材料; 用于选择适合于施用c-Met抑制剂的受试者的组合物，其包含检测所述生物标志物的材料; 用于使用该生物标志物预测和/或监测c-Met抑制剂的功效的方法; 用于选择适合于使用所述生物标志物应用c-Met抑制剂的受试者的方法; 以及用于预防和/或治疗癌症的方法，包括向所选择的受试者施用c-Met抑制剂。