公开(公告)号：US20180305319A1

公开(公告)日：2018-10-25

申请号：US15738016

申请日：2016-06-28

申请人： SANDOZ AG

发明人： Olga SCHÖNE ,  Hans-Peter Spitzenstätter ,  Marius KAUFMANN

IPC分类号： C07D231/40

CPC分类号： C07D231/40 ,  C07D501/46

摘要： The present invention relates to a process for the preparation of carbamoylamino pyrazole derivatives using diacetoxyiodobenzene (PhI(OAc)2) in combination with a non-nucleophilic base.

公开(公告)号：US10351533B2

公开(公告)日：2019-07-16

申请号：US15738016

申请日：2016-06-28

申请人： Sandoz AG

发明人： Olga Schöne ,  Hans-Peter Spitzenstätter ,  Marius Kaufmann

IPC分类号： C07D231/40 ,  C07D501/46

摘要： The present invention relates to a process for the preparation of carbamoylamino pyrazole derivatives using diacetoxyiodobenzene (PhI(OAc)2) in combination with a non-nucleophilic base.

公开(公告)号：US20180162896A1

公开(公告)日：2018-06-14

申请号：US15575771

申请日：2016-05-26

申请人： Sandoz AG

发明人： Thorsten Wilhelm ,  Olga Schöne ,  Hans-Peter Spitzenstätter

IPC分类号： C07H19/10

CPC分类号： C07H19/10 ,  C07H19/06 ,  C07H19/16 ,  C07H19/20

摘要： A process for preparing a nucleoside phosphoramidate, in particular to a process for preparing sofosbuvir, wherein a phosphoramidate derivative is used as starting material.

公开(公告)号：US20170218006A1

公开(公告)日：2017-08-03

申请号：US15500627

申请日：2015-07-31

申请人： Sandoz AG

发明人： Thorsten Wilhelm ,  Hans-Peter Spitzenstätter ,  Olga Schöne ,  Frank Richter ,  Erwin Schreiner

IPC分类号： C07H19/06 ,  C07F9/653 ,  C07F9/6521 ,  C07F9/572

CPC分类号： C07H19/06 ,  C07F9/572 ,  C07F9/6521 ,  C07F9/65324 ,  C07F9/65586

摘要： A process for the preparation of a compound of formula (I) including all isomers, stereoisomers, enantiomers and diastereomers thereof (I), and salts thereof; the process comprising providing a mixture comprising a compound of formula (II) and a compound of formula (III) subjecting the mixture provided in a) to reaction conditions in the presence of one or more Lewis acids to the mixture provided in a), obtaining a mixture comprising the compound of formula (I).