公开(公告)号：US10138235B2

公开(公告)日：2018-11-27

申请号：US15451955

申请日：2017-03-07

Applicant: SANOFI

Inventor： Chantal Alcouffe ,  Kirsten Bjegarde ,  Jacques Mauger

IPC: C07D471/04

Abstract: The invention relates to FGF-inhibiting pyrazolopyrimidine derivatives of general formula (I) to a process for preparing them and to the therapeutic use thereof.

公开(公告)号：US09732078B2

公开(公告)日：2017-08-15

申请号：US14370462

申请日：2013-01-03

Applicant: SANOFI

Inventor： Chantal Alcouffe ,  Corentin Herbert

IPC: C07D471/04 ,  A61K31/437

CPC classification number: C07D471/04 ,  A61K31/437

Abstract: The invention relates to the use of compounds corresponding to formula (I) in which R2 and R3 together form, with the carbon atoms of the phenyl nucleus to which they are attached, a 6-membered nitrogenous heterocycle corresponding to one of the formulae (A), (B) and (C) in which the wavy lines represent the phenyl nucleus to which R2 and R3 are attached, or of a pharmaceutically acceptable salt thereof, for preparing a medicament for the treatment of bladder cancer.

公开(公告)号：US09452164B2

公开(公告)日：2016-09-27

申请号：US14267272

申请日：2014-05-01

Applicant: SANOFI

Inventor： Chantal Alcouffe ,  Reinhard Kirsch ,  Corentin Herbert ,  Gilbert Lassalle

IPC: A01N43/32 ,  A61K31/44 ,  A61K31/517 ,  A61K31/437 ,  A61K9/20 ,  C07D211/82 ,  C07D211/90 ,  C07D233/64 ,  C07D233/88 ,  C07D233/90 ,  C07D471/04 ,  A61K31/5377 ,  A61K45/06

CPC classification number: A61K31/517 ,  A61K9/2018 ,  A61K9/2054 ,  A61K9/2059 ,  A61K31/437 ,  A61K31/5377 ,  A61K45/06 ,  C07D211/82 ,  C07D211/90 ,  C07D233/64 ,  C07D233/88 ,  C07D233/90 ,  C07D471/04

Abstract: The invention relates to compounds corresponding to formula (I): in which R2 and R3 together form, with the carbon atoms of the phenyl nucleus to which they are attached, a 6-membered nitrogenous heterocycle corresponding to one of formula (A), (B) or (C) below: in which the wavy lines represent the phenyl nucleus to which R2 and R3 are attached. Preparation process and therapeutic use.

Abstract translation: 制备过程和治疗用途。

公开(公告)号：US09572799B2

公开(公告)日：2017-02-21

申请号：US14897929

申请日：2014-06-13

Applicant: SANOFI

Inventor： Chantal Alcouffe

IPC: A61K31/44 ,  A61K31/437 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/5377

CPC classification number: A61K31/437 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/5377

Abstract: The invention relates to the use of compounds corresponding to formula (I), or a pharmaceutically acceptable salt thereof, for preparing a medicament for the treatment of bladder cancer.

Abstract translation: 本发明涉及对应于式（I）的化合物或其药学上可接受的盐在制备用于治疗膀胱癌的药物中的用途。

公开(公告)号：US20140350006A1

公开(公告)日：2014-11-27

申请号：US14364420

申请日：2012-12-13

Applicant: SANOFI

Inventor： Chantal Alcouffe ,  Kirsten Bjegarde ,  Jacques Mauger

IPC: C07D471/04 ,  A61K31/5377 ,  A61N5/10 ,  A61K45/06 ,  A61K31/4545 ,  A61K31/444 ,  A61K31/538 ,  A61K31/437

CPC classification number: A61K31/538 ,  A61K31/437 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/5377 ,  A61K45/06 ,  A61N5/10 ,  A61P35/00 ,  A61P35/04 ,  C07D471/04

Abstract: The invention relates to FGF-inhibiting pyrazolopyrimidine derivatives of general formula (I) to a process for preparing them and to the therapeutic use thereof.

Abstract translation: 本发明涉及通式（I）的FGF抑制吡唑并嘧啶衍生物及其制备方法及其治疗用途。

公开(公告)号：US20140343054A1

公开(公告)日：2014-11-20

申请号：US14370462

申请日：2013-01-03

Applicant: SANOFI

Inventor： Chantal Alcouffe ,  Corentin Herbert

IPC: C07D471/04

CPC classification number: C07D471/04 ,  A61K31/437

Abstract: The invention relates to the use of compounds corresponding to formula (I) in which R2 and R3 together form, with the carbon atoms of the phenyl nucleus to which they are attached, a 6-membered nitrogenous heterocycle corresponding to one of the formulae (A), (B) and (C) in which the wavy lines represent the phenyl nucleus to which R2 and R3 are attached, or of a pharmaceutically acceptable salt thereof, for preparing a medicament for the treatment of bladder cancer.

Abstract translation: 本发明涉及对应于式（I）的化合物的用途，其中R 2和R 3一起与其所连接的苯基的碳原子一起形成对应于式（A）之一的6元含氮杂环 ），（B）和（C），其中波浪线表示R2和R3所连接的苯基或其药学上可接受的盐，用于制备治疗膀胱癌的药物。