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公开(公告)号：US20160074381A1
公开(公告)日：2016-03-17
申请号：US14939600
申请日：2015-11-12
发明人： Wang SHEN , Kenneth BARR , Johan D. OSLOB , Min ZHONG
IPC分类号： A61K31/4725 , A61K31/517 , A61K31/472 , A61K45/06 , A61K31/506
CPC分类号： A61K31/4725 , A61K31/472 , A61K31/506 , A61K31/517 , A61K45/06 , C04B35/632 , C07D217/06 , C07D217/16 , C07D217/26 , C07D231/56 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14
摘要： The present invention provides compounds having formula (I): and pharmaceutically acceptable derivatives thereof, wherein R1-R4, n, p, A, B, D, E, L and AR1 are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof for the treatment of disorders mediated by the CD11/CD18 family of cellular adhesion molecules (e.g., LFA-1).
摘要翻译： 本发明提供了具有式（I）的化合物及其药学上可接受的衍生物，其中R 1 -R 4，n，p，A，B，D，E，L和AR 1如本文中一般和类别和亚类所述，另外 提供其药物组合物及其用于治疗CD11 / CD18家族细胞粘附分子（例如LFA-1）介导的病症的方法。
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公开(公告)号：US20190134022A1
公开(公告)日：2019-05-09
申请号：US16172197
申请日：2018-10-26
发明人： Wang SHEN , Kenneth BARR , Johan D. OSLOB , Min ZHONG
IPC分类号： A61K31/4725 , A61K31/517 , C04B35/632 , C07D401/06 , C07D405/14 , C07D217/16 , C07D217/26 , A61K31/472 , A61K45/06 , C07D409/14 , C07D409/12 , C07D405/12 , C07D405/06 , C07D403/14 , C07D403/12 , C07D401/14 , C07D401/12 , C07D231/56 , C07D217/06 , A61K31/506
摘要： The present invention provides compounds having formula (I): and pharmaceutically acceptable derivatives thereof, wherein R1-R4, n, p, A, B, D, E, L and AR1 are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof for the treatment of disorders mediated by the CD11/CD18 family of cellular adhesion molecules (e.g., LFA-1).
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公开(公告)号：US20140066476A1
公开(公告)日：2014-03-06
申请号：US13969968
申请日：2013-08-19
发明人： Wang SHEN , Kenneth BARR , Johan D. OSLOB , Min ZHONG
IPC分类号： A61K31/472 , A61K45/06 , C07D405/14 , A61K31/4725 , C07D401/12 , C07D405/06 , C07D217/26 , C07D401/06
CPC分类号： A61K31/4725 , A61K31/472 , A61K31/506 , A61K31/517 , A61K45/06 , C04B35/632 , C07D217/06 , C07D217/16 , C07D217/26 , C07D231/56 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14
摘要： The present invention provides compounds having formula (I): and pharmaceutically acceptable derivatives thereof, wherein R1-R4, n, p, A, B, D, E, L and AR1 are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof for the treatment of disorders mediated by the CD11/CD18 family of cellular adhesion molecules (e.g., LFA-1).
摘要翻译： 本发明提供了具有式（I）的化合物及其药学上可接受的衍生物，其中R 1 -R 4，n，p，A，B，D，E，L和AR 1如本文中一般和类别和亚类所述，另外 提供其药物组合物及其用于治疗CD11 / CD18家族细胞粘附分子（例如LFA-1）介导的病症的方法。
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公开(公告)号：US20140051675A1
公开(公告)日：2014-02-20
申请号：US13969915
申请日：2013-08-19
发明人： Wang SHEN , Kenneth BARR , Johan D. OSLOB , Min ZHONG
IPC分类号： C07D409/14 , C07D405/14 , C07D231/56 , C07D217/16 , C07D401/06 , C07D409/12 , C07D401/12
CPC分类号： A61K31/4725 , A61K31/472 , A61K31/506 , A61K31/517 , A61K45/06 , C04B35/632 , C07D217/06 , C07D217/16 , C07D217/26 , C07D231/56 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14
摘要： The present invention provides compounds having formula (I): and pharmaceutically acceptable derivatives thereof, wherein R1-R4, n, p, A, B, D, E, L and AR1 are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof for the treatment of disorders mediated by the CD11/CD18 family of cellular adhesion molecules (e.g., LFA-1).
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