Polyunsaturated fatty acid monoglycerides, compositions, methods and uses thereof

    公开(公告)号:US11166933B2

    公开(公告)日:2021-11-09

    申请号:US17052302

    申请日:2019-05-03

    Inventor: Samuel C. Fortin

    Abstract: There are provided various compounds and compositions comprising polyunsaturated fatty acid monoglycerides and derivatives thereof. These compounds and compositions can be useful for use as prebiotic in a subject; for the modulation of the microbiota composition; for enhancing the population of good bacteria like Akkermansia muciniphila and for enhancing the efficacy of cancer immunotherapy of a subject. These compounds and compositions comprise at least one compound chosen from formula (I), (II), (III), (IV).

    Polyunsaturated fatty acid monoglycerides, compositions, methods and uses thereof

    公开(公告)号:US10716776B2

    公开(公告)日:2020-07-21

    申请号:US16517607

    申请日:2019-07-21

    Inventor: Samuel C. Fortin

    Abstract: There are provided various compounds and compositions comprising polyunsaturated fatty acid monoglycerides and derivatives thereof. These compounds and compositions can be useful for increasing the life span of a subject; for increasing the disability-free life expectancy, for slowing down the ageing process of a subject; for increasing the mitochondrial OXPHOS of a subject; for decreasing the mitochondrial LEAK of a subject; for increasing the mitochondrial RCR or COUPLING EFFICIENCY of a subject; and for optimizing the mitochondrial functions of a subject. These compounds and compositions comprise at least one compound chosen from

    Polyunsaturated fatty acid monoglycerides, derivatives, and uses thereof
    7.
    发明授权
    Polyunsaturated fatty acid monoglycerides, derivatives, and uses thereof 有权
    多不饱和脂肪酸单甘油酯,衍生物及其用途

    公开(公告)号:US09447020B2

    公开(公告)日:2016-09-20

    申请号:US14525621

    申请日:2014-10-28

    Inventor: Samuel C. Fortin

    CPC classification number: C07C69/732 C07D303/16

    Abstract: There are provided compounds of formula (I): wherein X1 is O, NH, or S; X2 is O, NH, or S; and X3 is O, NH, or S; and wherein R, R1, T1 and T2 can represent various entities. Such compounds can be useful, for example, for preventing, palliating or treating various diseases such as heart diseases, respiratory diseases, treating inflammatory abnormalities, metabolic disorders or diabetes.

    Abstract translation: 这样的化合物可用于例如预防,缓解或治疗各种疾病如心脏病,呼吸系统疾病,治疗炎性异常,代谢紊乱或糖尿病。

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