公开(公告)号：US20020123504A1

公开(公告)日：2002-09-05

申请号：US10082685

申请日：2002-02-25

Applicant: SEPRACOR INC.

Inventor： Martin P. Redmon ,  Hal T. Butler ,  Stephen A. Wald ,  Paul D. Rubin

IPC: A61K031/473 ,  A61K031/192

CPC classification number: A61K31/621 ,  A61K9/2009 ,  A61K9/2013 ,  A61K9/2018 ,  A61K9/2054 ,  A61K9/2059 ,  A61K31/16 ,  A61K31/445 ,  A61K31/4545 ,  A61K31/473 ,  A61K31/60 ,  A61K2300/00

Abstract: Stable pharmaceutical compositions of descarboethoxyloratadine (DCL), a metabolic derivative of loratadine, for the treatment of allergic rhinitis and other histamine-induced disorders are disclosed. The compositions are formulated to avoid the incompatibility between DCL and reactive excipients such as lactose and other mono- and di-saccharides. Disclosed compositions include lactose-free, non-hygroscopic and anhydrous stable pharmaceutical compositions of DCL.

Abstract translation: 公开了用于治疗过敏性鼻炎和其他组胺诱导的疾病的去甲氧基乙酰氨喋呤（DCL）的稳定的药物组合物，其是氯雷他定的代谢衍生物。 配制组合物以避免DCL和反应性赋形剂如乳糖和其它单糖和二糖之间的不相容性。 公开的组合物包括无乳糖，非吸湿性和无水稳定的DCL药物组合物。

公开(公告)号：US20030100581A1

公开(公告)日：2003-05-29

申请号：US09907556

申请日：2001-07-17

Applicant: SEPRACOR INC.

Inventor： Roger P. Bakale ,  Chris Senanayake ,  Yaping Hong ,  Kostas Saranteas ,  Martin P. Redmon ,  Stephen A. Wald

IPC: A61K031/454 ,  C07D43/02

CPC classification number: C07D401/12

Abstract: Polymorphic crystalline forms of the antihistaminic drug norastemizole are disclosed. Processes for the production of the preferred polymorph are also disclosed.

Abstract translation: 公开了抗组胺药物诺尔阿司咪唑的多晶型形式。 还公开了制备优选多晶型物的方法。