公开(公告)号：US20230022783A1

公开(公告)日：2023-01-26

申请号：US17855823

申请日：2022-07-01

申请人： SERICULTURAL&AGRI-FOOD RESEARCH INSTITUTE GUANGDONG ACADEMY OF AGRICULTURAL SCIENCES

发明人： MINGWEI ZHANG ,  YUNAYUAN DENG ,  GUANG LIU ,  YAN ZHANG ,  ZHENCHENG WEI ,  PENGFEI ZHOU ,  PING LI ,  ZHIHAO ZHAO ,  XUCHAO JIA ,  XIAOJUN TANG

IPC分类号： C07D407/12 ,  A61K36/42

摘要： The present invention relates to the technical field of natural medicines, and in particular to a triterpenoid compound with an effect of improving glucose and lipid metabolism disorders, and preparation and application thereof. A novel triterpenoid compound was obtained by separation from Momordica charantia L. for the first time in the present invention. Studies on a mouse primary hepatocyte model and a 3T3-L1 preadipocyte model show that the novel triterpenoid compound in the present invention has activity of regulating glucose and lipid metabolism, and after combination with known triterpenoid compound Momordicoside G, the activity of regulating glucose and lipid metabolism is significantly higher than that of a single compound at the same dose, indicating that the novel triterpenoid compound and a complex thereof in the present invention can be used to improve glucose and lipid metabolism disorders and provide a new way for diabetes treatment.