公开(公告)号：US20190290638A1

公开(公告)日：2019-09-26

申请号：US16436590

申请日：2019-06-10

申请人： Serina Therapeutics, Inc.

发明人： Randall MOREADITH ,  Michael BENTLEY ,  Kunsang YOON ,  Zhihao FANG ,  Rebecca WEIMER ,  Bekir DIZMAN ,  Tacey VIEGAS

IPC分类号： A61K31/4745 ,  A61K47/61 ,  A61K47/54 ,  A61K47/60 ,  A61K31/7048 ,  A61K31/381 ,  A61K31/4462 ,  A61K31/4535 ,  A61K31/4045 ,  A61K9/00

摘要： The present disclosure provides polymer conjugates comprising a polymer and an agent, the agent linked to the polymer via a linking group containing a hydrolyzable moiety.

公开(公告)号：US20160303250A1

公开(公告)日：2016-10-20

申请号：US15197336

申请日：2016-06-29

申请人： SERINA THERAPEUTICS, INC.

发明人： Randall MOREADITH ,  Michael David BENTLEY ,  Kunsang YOON ,  Zhihao FANG ,  Rebecca WEIMER ,  Bekir DIZMAN ,  Tacey VIEGAS

IPC分类号： A61K47/48 ,  A61K31/4045 ,  A61K31/381

CPC分类号： A61K31/4745 ,  A61K9/0019 ,  A61K31/381 ,  A61K31/4045 ,  A61K31/4462 ,  A61K31/4535 ,  A61K31/7048 ,  A61K47/542 ,  A61K47/60 ,  A61K47/61

摘要： The present disclosure provides polymer conjugates comprising a polymer and an agent, the agent linked to the polymer via a linking group containing a hydrolyzable moiety.

摘要翻译： 本公开提供了包含聚合物和试剂的聚合物共轭物，所述试剂通过含有可水解部分的连接基与聚合物连接。

公开(公告)号：US20230009076A1

公开(公告)日：2023-01-12

申请号：US17621613

申请日：2020-06-28

申请人： SERINA THERAPEUTICS, INC.

发明人： J Milton HARRIS ,  Michael D BENTLEY ,  Tacey X VIEGAS ,  Randall W MOREADITH ,  Zhihao FANG ,  Kunsang YOON ,  Rebecca WEIMER

IPC分类号： A61K47/59 ,  A61K31/05

摘要： The present disclosure provides for polyoxazoline (POZ) conjugates wherein the conformation of the POZ conjugate and the release rate of an agent from the POZ conjugate can be controlled by selecting one or more characteristics of the POZ polymer. Methods of controlling the conformation of a POZ conjugate and the release rate of an agent prior are provided as well as methods of treatment using such POZ conjugates and methods. Pharmaceutical compositions comprising a POZ conjugate are also provided.

公开(公告)号：US20210186957A1

公开(公告)日：2021-06-24

申请号：US17263723

申请日：2019-07-27

申请人： SERINA THERAPEUTICS, INC.

发明人： Michael BENTLEY ,  Zhihao FANG ,  Rebecca WEIMER ,  Tacey VIEGAS ,  Randall MOREADITH

IPC分类号： A61K31/485 ,  A61K47/59 ,  A61K47/20 ,  A61K47/18 ,  A61K47/14 ,  A61K31/137 ,  A61K31/15 ,  A61K31/277 ,  A61K31/55 ,  A61K31/198 ,  A61K31/05 ,  A61K31/24 ,  A61K31/36 ,  A61K31/12 ,  A61K9/00 ,  A61K47/22

摘要： Described are conjugates comprising a water-soluble polymer linked to a compound comprising a catechol moiety via a cleavable linkage, wherein the cleavable linkage is formed between the water-soluble polymer and a first phenolic hydroxyl group e of the catechol moiety and a second phenolic hydroxyl group of the catechol moiety is linked to a blocking group wherein the rate of hydrolytic release of the compound comprising the catechol moiety is controlled, at least in part, through structure or design of the blocking group on the second phenolic hydroxyl group of the catechol moiety. Therefore, the rate of hydrolytic release of the compound comprising the catechol moiety can be tuned through structural design of the group on the second phenolic hydroxyl group of the catechol moiety. Compounds used in the synthesis of the described conjugates and methods of using the described conjugate and other compounds in the treatment of dopamine-responsive disorders are also described.