利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

6 条记录 (耗时 0.015 秒)

    Multifunctional Forms of Polyoxazoline Copolymers and Drug Compositions Comprising the Same
    2.
    发明申请
    Multifunctional Forms of Polyoxazoline Copolymers and Drug Compositions Comprising the Same 审中-公开
    多官能团形式的聚恶唑啉共聚物和药物组合物组成

    公开(公告)号：US20140066577A1

    公开(公告)日：2014-03-06

    申请号：US13957989

    申请日：2013-08-02

    申请人： Serina Therapeutics, Inc.

    发明人： Kunsang YOON ,  J. Milton HARRIS ,  Michael David BENTLEY ,  Zhihac FANG ,  Tacey VIEGAS

    IPC分类号： A61K47/48

    CPC分类号： A61K47/59 ,  A61K38/09 ,  C08G73/0233

    摘要： The present disclosure provides copolymers of 2-substituted-2-oxazolines possessing two or three reactive functional groups which are also chemically orthogonal. The copolymers described may be random copolymers, block copolymers or a mixture of random and block copolymer configurations. Furthermore, the present disclosure provides novel methods for synthesizing the above polymers and for conjugating to molecules such as targeting, diagnostic and therapeutic agents.

    摘要翻译： 本公开提供了具有两个或三个也是化学正交的反应性官能团的2-取代-2-恶唑啉的共聚物。 所述共聚物可以是无规共聚物，嵌段共聚物或无规嵌段共聚物构型的混合物。 此外，本公开提供了用于合成上述聚合物并用于与靶标，诊断和治疗剂等分子缀合的新方法。

    Multifunctional Forms of Polyoxazoline Copolymers and Drug Compositions Comprising the Same
    4.
    发明申请
    Multifunctional Forms of Polyoxazoline Copolymers and Drug Compositions Comprising the Same 审中-公开
    多官能团形式的聚恶唑啉共聚物和药物组合物组成

    公开(公告)号：US20150273074A1

    公开(公告)日：2015-10-01

    申请号：US14627555

    申请日：2015-02-20

    申请人： SERINA THERAPEUTICS, INC.

    发明人： J. Milton HARRIS ,  Kunsang YOON ,  Michael David BENTLEY ,  Zhihao FANG ,  Tacey VIEGAS

    IPC分类号： A61K47/48 ,  C08G69/48 ,  C08G69/00

    CPC分类号： A61K47/59 ,  A61K38/09 ,  C08G73/0233

    摘要： The present disclosure provides copolymers of 2-substituted-2-oxazolines possessing two or three reactive functional groups which are also chemically orthogonal. The copolymers described may be random copolymers, block copolymers or a mixture of random and block copolymer configurations. Furthermore, the present disclosure provides novel methods for synthesizing the above polymers find for conjugating to molecules such as targeting, diagnostic and therapeutic agents.

    摘要翻译： 本公开提供了具有两个或三个也是化学正交的反应性官能团的2-取代-2-恶唑啉的共聚物。 所述共聚物可以是无规共聚物，嵌段共聚物或无规嵌段共聚物构型的混合物。 此外，本公开提供用于合成上述聚合物的新颖方法，用于与靶标，诊断和治疗剂等分子缀合。

    Polyoxazolines with Inert Terminating Groups, Polyoxazolines Prepared from Protected Initiating Groups and Related Compounds
    6.
    发明申请
    Polyoxazolines with Inert Terminating Groups, Polyoxazolines Prepared from Protected Initiating Groups and Related Compounds 有权
    具有惰性终止基团的聚恶唑啉，由保护起始基团和相关化合物制备的聚恶唑啉

    公开(公告)号：US20150080538A1

    公开(公告)日：2015-03-19

    申请号：US14537516

    申请日：2014-11-10

    申请人： SERINA THERAPEUTICS, INC.

    发明人： Michael D. BENTLEY ,  J. Milton HARRIS ,  Kunsang YOON ,  Michael REIF ,  Rainer JORDAN

    IPC分类号： C08G73/02

    CPC分类号： C08G73/0233 ,  A61K9/1272 ,  C08L79/02

    摘要： The present disclosure provides novel functional polyoxazoline derivatives prepared by terminating polyoxazoline polymerization with inert chemical groups. In addition, the present disclosure demonstrates the synthesis of novel electrophilic initiators with protected functional groups capable of initiating oxazoline polymerization and capable of surviving the conditions of polymerization. These initiators are used to synthesize the above inert-terminal polyoxazoline derivatives as well as other polyoxazolines with active terminal groups. Furthermore, the present disclosure provides for polyoxazoline-lipid conjugates and liposomal compositions prepared using such polyoxazoline-lipid conjugates. Methods of using the foregoing to prepare conjugates with target molecules are also disclosed.

    摘要翻译： 本公开提供通过用惰性化学基团终止聚恶唑啉聚合制备的新型功能性聚恶唑啉衍生物。 此外，本公开内容显示了具有能够引发恶唑啉聚合并能够在聚合条件下存活的受保护官能团的新型亲电子引发剂的合成。 这些引发剂用于合成上述惰性末端聚恶唑啉衍生物以及具有活性末端基团的其它聚恶唑啉。 此外，本公开提供使用这种聚恶唑啉 - 脂质缀合物制备的聚恶唑啉 - 脂质缀合物和脂质体组合物。 还公开了使用前述物质与靶分子制备缀合物的方法。