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![2,6-DIOXASPIRO [4,5] DECANE DERIVATIVES AND PREPARATION METHOD THEREFOR AND PHARMACEUTICAL APPLICATIONS THEREOF](/abs-image/US/2020/08/13/US20200255444A1/abs.jpg.150x150.jpg)
1.发明申请公开(公告)号：US20200255444A1
公开(公告)日：2020-08-13
申请号：US16755551
申请日：2018-10-12
发明人： Yang ZHANG , Wentao WU , Guangwen YANG , Zhixiang LI , Jikui SUN , Jie LI , Jian LI , Shuhui CHEN
IPC分类号： C07D493/10 , A61P23/00
摘要： The present invention relates to a series of 2,6-dioxaspiro [4,5] decane derivatives and applications thereof in preparation of opiate receptor p agonist related drugs; and in particular relates to the derivative compounds shown in formula (I), tautomers thereof or pharmaceutically acceptable compositions thereof.
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公开(公告)号：US20210403485A1
公开(公告)日：2021-12-30
申请号：US17281209
申请日：2019-09-29
发明人： Jianfei WANG , Yang ZHANG , Jikui SUN , Shuhui CHEN
IPC分类号： C07D498/22 , A61P35/00
摘要： The present invention discloses a compound of formula (II), a tautomer thereof or a pharmaceutically acceptable salt thereof, and relates to use thereof in preparing a medicament for treating solid tumor-related diseases.
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公开(公告)号：US20190169140A1
公开(公告)日：2019-06-06
申请号：US16322914
申请日：2017-08-02
发明人： Yang ZHANG , Zhifei FU , Miaorong LUO , Jian LI , Shuhui CHEN
IPC分类号： C07D271/04 , A61P35/00 , C07D413/14 , C07D413/12
摘要： A compound as an indoleamine-2,3-dioxygenase 1 (IDO1) inhibitor, and an application thereof in the field of IDO1-related diseases, and in particular a compound as shown in formula (I) and a pharmaceutically acceptable salts thereof.
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