公开(公告)号：US09737517B2

公开(公告)日：2017-08-22

申请号：US14888797

申请日：2014-05-04

Applicant: SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

Inventor： Hong Liu ,  Xin Xie ,  Haifeng Sun ,  Jing Li ,  Fei Zhao ,  Ying Chen ,  Zeng Li ,  Yu Zhou ,  Hualiang Jiang ,  Kaixian Chen

IPC: A61K31/4375

CPC classification number: A61K31/4375

Abstract: Use of hexahydro-dibenzo[a,g]quinolizine compounds as shown in formula(I) in preparing a medicine for treating and/or preventing benign prostate hyperplasia diseases.

公开(公告)号：US20190194185A1

公开(公告)日：2019-06-27

申请号：US16089713

申请日：2017-03-29

Applicant: Shanghai Institute of Materia Medica, Chinese Academy of Sciences

Inventor： Hong Liu ,  Yiping Wang ,  Fei Zhao ,  Jing Zhao ,  Jiang Wang ,  Cong Xi ,  Chenglin Wu ,  Hao Shen ,  Xu Han ,  Hualiang Jiang ,  Kaixian Chen

IPC: C07D459/00 ,  C07D495/22 ,  A61P3/06

CPC classification number: C07D459/00 ,  A61K31/4745 ,  A61P3/06 ,  C07D471/14 ,  C07D491/22 ,  C07D495/22

Abstract: The present invention relates to phenyl [a]indole[2,3-g]quinolizine compounds represented by formula (I), a preparation method therefor, a pharmaceutical composition, and applications thereof. Specific applications are applications in the preparation of drugs for treating diseases related to a proprotein convertase subtilisin Kexin-9 (PCSK9), comprising the applications in the preparation of drugs for treating hyperlipemia, hypercholesterolemia, hypertriglyceridemia, fatty liver deformation, atherosclerosis, obesity and other metabolic diseases.

公开(公告)号：US10927107B2

公开(公告)日：2021-02-23

申请号：US16089713

申请日：2017-03-29

Applicant: Shanghai Institute of Materia Medica, Chinese Academy of Sciences

Inventor： Hong Liu ,  Yiping Wang ,  Fei Zhao ,  Jing Zhao ,  Jiang Wang ,  Cong Xi ,  Chenglin Wu ,  Hao Shen ,  Xu Han ,  Hualiang Jiang ,  Kaixian Chen

IPC: C07D459/00 ,  C07D495/22 ,  A61K31/4745 ,  C07D491/22 ,  C07D471/14 ,  A61P3/06

Abstract: The present invention relates to phenyl [a]indole[2,3-g]quinolizine compounds represented by formula (I), a preparation method therefor, a pharmaceutical composition, and applications thereof. Specific applications are applications in the preparation of drugs for treating diseases related to a proprotein convertase subtilisin Kexin-9 (PCSK9), comprising the applications in the preparation of drugs for treating hyperlipemia, hypercholesterolemia, hypertriglyceridemia, fatty liver deformation, atherosclerosis, obesity and other metabolic diseases.