公开(公告)号：US20250122148A1

公开(公告)日：2025-04-17

申请号：US18728641

申请日：2023-01-10

Applicant: SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

Inventor： Fajun NAN ,  Zhaobing GAO ,  Wuheng DONG ,  Yueming ZHENG ,  Jintao WANG ,  Xiaoyu ZHOU ,  Huanan LIU ,  Haiyan XU

IPC: C07C269/04 ,  A61K31/27 ,  A61P21/00

Abstract: Disclosed are a high-selectivity KCNQ4 potassium channel agonist of formula I, a preparation method therefor and the use thereof. The compound further improves the KCNQ4 agonistic activity, and is still free of KCNQ2 agonistic activity, thus having excellent KCNQ4/KCNQ2 selectivity. The high-selectivity KCNQ4 agonist overcomes the defect of poor selectivity of existing potassium channel agonists, the activity is relatively increased, and the toxicity is remarkably reduced. The agonist also has a simpler structure and lower product cost, thereby having a better development prospect.