公开(公告)号：US20180064696A1

公开(公告)日：2018-03-08

申请号：US15556932

申请日：2016-03-03

Applicant: SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

Inventor： Fajun NAN ,  Boliang LI ,  Yang ZHAN ,  Xiaowei ZHANG ,  Ying XIONG ,  Xichan HU ,  Yangming ZHANG

IPC: A61K31/4433 ,  A61K31/352 ,  C07D493/04

CPC classification number: A61K31/4433 ,  A61K31/352 ,  C07B37/04 ,  C07B49/00 ,  C07D493/04

Abstract: The present invention relates to a series of analogues of natural product Pyripyropene A represented by general formula I and a preparation method and use thereof. More particularly, the present invention relates to analogues of the natural product Pyripyropene A, a preparation method and use thereof as the acyl-CoA:cholesterol acyltransferase 2 (ACAT2) inhibitors for the treatment of cardiovascular diseases such as atherosclerosis and the like.