-
公开(公告)号：US11905296B2
公开(公告)日：2024-02-20
申请号：US17790042
申请日：2021-01-27
申请人： AZAD PHARMA AG
发明人： Hartmut Zinser , Tamar Danielyan , Meri Grigoryan , Mariam Gharibyan , Mikayel Movsisyan , Kristine Nerkararyan
IPC分类号： C07D489/12 , C07B49/00 , C07B43/08 , C07B43/04 , C07B31/00 , C07B37/12 , C07D498/12 , A61P25/36 , A61P25/04
CPC分类号： C07D489/12 , A61P25/04 , A61P25/36 , C07B31/00 , C07B37/12 , C07B43/04 , C07B43/08 , C07B49/00 , C07D498/12 , C07D489/12 , C07B49/00 , C07D489/12 , C07B43/08 , C07D489/12 , C07B43/04 , C07D489/12 , C07B31/00 , C07D489/12 , C07B37/12
摘要： The present invention relates to a novel route of synthesis for the opioid receptor antagonist Buprenorphine or a pharmaceutically acceptable salt thereof, starting from thebaine, wherein the route comprises the reaction of thebaine with a dienophile; forming an alkylated reaction product by reaction with a Grignard-reagent; formation of an cyanamide; deprotection of the cyanamide- and the phenolic-oxygen-moiety, wherein the cleavage of one or both groups is performed in the presence of an alkali or alkaline earth sulfide; followed by derivatization with a cyclopropyl-halogen and hydrogenation to yield Buprenorphine.
-
公开(公告)号：US11851404B2
公开(公告)日：2023-12-26
申请号：US17676077
申请日：2022-02-18
申请人： DSM IP ASSETS B.V.
IPC分类号： C07C67/293 , C07B49/00 , C07C403/08 , C07C403/12 , C07C69/145
CPC分类号： C07C67/293 , C07B49/00 , C07C403/08 , C07C403/12 , C07C69/145
摘要： Processes for synthesizing new compounds that may usefully be employed in organic synthesis, especially in the synthesis of vitamin A or β-carotene and derivatives thereof, e.g. canthaxanthin, astaxanthin or zeaxanthin are disclosed. The new compounds are especially useful as intermediates (building blocks) in the synthesis of vitamin A or β-carotene, preferably vitamin A.
-
公开(公告)号：US20180170886A1
公开(公告)日：2018-06-21
申请号：US15571113
申请日：2016-05-12
申请人： DSM IP ASSETS B.V.
IPC分类号： C07D251/24 , C07D251/20 , C07B49/00 , C07B63/00
CPC分类号： C07D251/24 , C07B49/00 , C07B63/00 , C07D251/20 , C07F3/02
摘要： The invention relates to an improved process for the manufacture of bis-resorcinyl triazines of formula (I) wherein R1 is a C1C18alkyl group or C2-C18alkenyl group as well as the respective alkyl substituted bis-resorcinyl derivatives of formula (II) wherein R1 is a C1-C18alkyl group or C2-C18alkenyl group and R2 and R3 are independently of each other a C1-C18alkyl group or a C2-C18alkenyl group.
-
公开(公告)号：US20180162805A1
公开(公告)日：2018-06-14
申请号：US15580517
申请日：2015-06-09
发明人： Zunjun LIANG , Weifeng XIAO , Caihua PENG , Wenfeng HUANG , Guoliang TU
IPC分类号： C07C253/30 , C07C255/59 , C07B49/00 , C07F3/02
CPC分类号： C07C253/30 , C07B49/00 , C07B2200/07 , C07C255/59 , C07F3/02
摘要： The present invention relates to a method for preparing a citalopram diol represented by formula IV, comprising the following steps: in the existence of an auxiliary reagent of metal salt, allowing 5-cyanophthalide to sequentially subjected to Grignard addition reactions with p-fluorophenyl magnesium halide and N, N-dimethylaminopropyl magnesium halide in an organic solvent; and after the reactions are completed, performing hydrolysis and separation to obtain citalopram diol represented by formula IV. In the present invention, by adding an auxiliary reagent of metal salt, the activity and the selectivity of the Grignard reactions are remarkably improved, and the reaction yield is obviously enhanced.
-
公开(公告)号：US09969768B1
公开(公告)日：2018-05-15
申请号：US15815587
申请日：2017-11-16
申请人： KING SAUD UNIVERSITY
IPC分类号： C07J63/00 , C07J53/00 , C07D213/36 , A61K31/56 , C07B43/04 , C07B49/00 , C07D265/30
CPC分类号： C07J63/008 , A61K31/56 , C07B43/04 , C07B49/00 , C07D213/36 , C07D265/30 , C07J53/002
摘要： Oleanolic acid methyl ester derivatives demonstrate potent anti-diabetic activities. In in vitro anti-diabetic testing, the derivatives showed more potency regarding dipeptidyl peptidase-4 (DPP-IV) inhibitor activity, peroxisome proliferator-activated receptors (PPARs) agonist activity, and α-Glucosidase inhibitors activity, as compared to reference standards oleanolic acid and acarbose. In in vivo oral hypoglycemic testing, both acute and sub-acute studies demonstrated that the derivatives had high potency and long duration of action compared to the reference standards pioglitazone, acarbose and oleanolic acid.
-
公开(公告)号：US20150141689A1
公开(公告)日：2015-05-21
申请号：US14368899
申请日：2012-12-25
IPC分类号： C07F7/18
CPC分类号： C07F7/1876 , C07B49/00 , C07F7/0827 , C07F7/122
摘要： A method of producing an organic silicon compound includes a step of reaction of the following: (A) a reactive silane compound represented by General Formula (1) below: R1mSiY(4-m) (wherein R1 is a monovalent organic group (except for the group represented by Y) or a hydrogen atom; Y indicates a chlorine atom or a group represented by —OR2; R2 indicates a monovalent hydrocarbon group having 1 to 30 carbon atoms; and m is a number in the range of 0 to 3), (B) a halogenated organic compound represented by General Formula (2) below: R3-X (wherein R3 indicates a monovalent organic group; and X is a halogen atom), and (C) metallic magnesium (Mg) in the presence of (D) an organic solvent containing at least one type of ether type compound.
摘要翻译： 有机硅化合物的制造方法包括以下步骤：（A）由通式（1）表示的反应性硅烷化合物：R1mSiY（4-m）（其中R1是一价有机基团（除 Y表示的基团或氢原子; Y表示氯原子或-OR2表示的基团; R2表示碳原子数1〜30的一价烃基，m表示0〜3的数） ，（B）下述通式（2）表示的卤代有机化合物：R3-X（其中R3表示一价有机基团，X表示卤素原子），（C）金属镁（Mg） （D）含有至少一种醚型化合物的有机溶剂。
-
公开(公告)号：US08288508B2
公开(公告)日：2012-10-16
申请号：US11849229
申请日：2007-08-31
IPC分类号： C08G61/00
摘要： Universal Grignard Metathesis (GRIM) reactions which provide access to conjugated polymers by GRIM methods. A method comprising: providing an unsaturated ring compound comprising at least two halogen ring substituents, providing an organomagnesium reagent comprising an organomagnesium component and a metal activation agent, combining the unsaturated ring compound with the reagent to form a second compound by metal-halogen exchange, wherein the metal activation agent activates the metal-halogen exchange, coupling the second compound to itself in an oligomerization or polymerization reaction. Metal activation agent can be lithium chloride. The process is commercially attractive and can be executed in good yields. Polyfluorenes, polypyrroles, and polythiophenes can be prepared for use in OLED, PLED, photovoltaic, transistor, antistatic coatings, and sensor applications.
摘要翻译： 通用Grignard复分解（GRIM）反应，通过GRIM方法提供对共轭聚合物的接触。 一种方法，包括：提供包含至少两个卤素环取代基的不饱和环化合物，提供包含有机镁组分和金属活化剂的有机镁试剂，将不饱和环化合物与试剂结合以通过金属 - 卤素交换形成第二化合物， 其中所述金属活化剂活化所述金属 - 卤素交换，在低聚反应或聚合反应中将所述第二化合物偶联至其自身。 金属活化剂可以是氯化锂。 该方法具有商业上的吸引力，可以以良好的产率进行。 聚芴，聚吡咯和聚噻吩可以制备用于OLED，PLED，光伏，晶体管，抗静电涂层和传感器应用。
-
公开(公告)号：US07553924B2
公开(公告)日：2009-06-30
申请号：US10875072
申请日：2004-06-23
申请人： Lan-Chang Liang
发明人： Lan-Chang Liang
CPC分类号： C07C45/68 , B01J31/189 , B01J2231/4205 , B01J2231/4261 , B01J2231/48 , B01J2531/824 , B01J2531/847 , C07B37/04 , C07B49/00 , C07C1/325 , C07C1/326 , C07C2/861 , C07C47/548 , C07C49/796 , C07C201/12 , C07C2531/24 , C08G63/823 , C07C205/06
摘要： The present invention mainly relates to a carbon-carbon bond formation catalyzed by a complex comprising a novel and stable ligand and a metal center. The ligand uses a ring, particularly a phenyl group, or a hydrocarbon group to link an amino group and PR1R2, NR1R2, OR1, SR1, or AsR1R2 group for stabling the structure of the ligand.
摘要翻译： 本发明主要涉及由包含新颖且稳定的配体和金属中心的络合物催化的碳 - 碳键形成。 配体使用环，特别是苯基或烃基连接氨基和PR1R2，NR1R2，OR1，SR1或AsR1R2基团以稳定配体的结构。
-
9.发明授权Grignard processes with improved yields of diphenylchlorosilanes as products 失效Grignard工艺具有提高的二苯基氯硅烷的产率作为产品公开(公告)号：US07456308B2
公开(公告)日：2008-11-25
申请号：US10585154
申请日：2004-12-17
申请人： Binh Thanh Nguyen , Curtis John Bedbury , Roger Edwin Humburg , Susan Mary Jacob , Sarah Jane Ratcliff , John Dennis Waterman
发明人： Binh Thanh Nguyen , Curtis John Bedbury , Roger Edwin Humburg , Susan Mary Jacob , Sarah Jane Ratcliff , John Dennis Waterman
IPC分类号： C07F7/04
摘要： A Grignard process for preparing phenyl-containing chlorosilane products, in particular diphenylchlorosilanes, is carried out in three embodiments. In the first embodiment, the reactants of the Grignard process are a phenyl Grignard reagent, an ether solvent, a trichlorosilane, and an aromatic hydrocarbon coupling solvent. In the second embodiment, the reactants of the Grignard process are a phenyl Grignard reagent, an ether solvent, a phenylchlorosilane, and an aromatic hydrocarbon coupling solvent. In the third embodiment, the reactants of the Grignard process are a phenyl Grignard reagent, an ether solvent, a trichlorosilane, a phenylchlorosilane, and an aromatic hydrocarbon coupling solvent. In each embodiment, the reactants are present in a particular mole ratio.
摘要翻译： 用于制备含苯基氯硅烷产物，特别是二苯基氯硅烷的格氏法是在三个实施方案中进行的。 在第一实施方案中，格氏法的反应物是苯基格氏试剂，醚溶剂，三氯硅烷和芳族烃偶合溶剂。 在第二实施方案中，格氏法的反应物是苯基格氏试剂，醚溶剂，苯基氯硅烷和芳族烃偶联溶剂。 在第三实施方案中，格氏法的反应物是苯基格氏试剂，醚溶剂，三氯硅烷，苯基氯硅烷和芳烃耦合溶剂。 在每个实施方案中，反应物以特定的摩尔比存在。
-
公开(公告)号：US20080146754A1
公开(公告)日：2008-06-19
申请号：US11849229
申请日：2007-08-31
IPC分类号： C08F2/00
摘要： Universal Grignard Metathesis (GRIM) reactions which provide access to conjugated polymers by GRIM methods. A method comprising: providing an unsaturated ring compound comprising at least two halogen ring substituents, providing an organomagnesium reagent comprising an organomagnesium component and a metal activation agent, combining the unsaturated ring compound with the reagent to form a second compound by metal-halogen exchange, wherein the metal activation agent activates the metal-halogen exchange, coupling the second compound to itself in an oligomerization or polymerization reaction. Metal activation agent can be lithium chloride. The process is commercially attractive and can be executed in good yields. Polyfluorenes, polypyrroles, and polythiophenes can be prepared for use in OLED, PLED, photovoltaic, transistor, antistatic coatings, and sensor applications.
摘要翻译： 通用Grignard复分解（GRIM）反应，通过GRIM方法提供对共轭聚合物的接触。 一种方法，包括：提供包含至少两个卤素取代基的不饱和环化合物，提供包含有机镁组分和金属活化剂的有机镁试剂，将不饱和环化合物与试剂结合以通过金属 - 卤素交换形成第二化合物， 其中所述金属活化剂活化所述金属 - 卤素交换，在低聚反应或聚合反应中将所述第二化合物偶联至其自身。 金属活化剂可以是氯化锂。 该方法具有商业上的吸引力，可以以良好的产率进行。 聚芴，聚吡咯和聚噻吩可以制备用于OLED，PLED，光伏，晶体管，抗静电涂层和传感器应用。
-
-
-
-
-
-
-
-
-
搜索结果
82 条记录 (耗时 0.025 秒)
