公开(公告)号：US20190218540A1

公开(公告)日：2019-07-18

申请号：US16327270

申请日：2017-08-22

Applicant: SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

Inventor： Kan DING ,  Yanling LI

IPC: C12N9/90 ,  C12N15/90 ,  A61K49/00 ,  A01K67/027

CPC classification number: C12N9/90 ,  A01K67/0276 ,  A01K2217/075 ,  A01K2217/077 ,  A01K2217/15 ,  A01K2227/105 ,  A01K2267/0362 ,  A61K49/00 ,  A61K49/0008 ,  C12N15/90 ,  C12N15/907 ,  C12Y501/03017

Abstract: A method for preparing a model of an animal suffering from non-human mammal obesity or a related disease, comprising the following steps: (a) providing a cell of a non-human mammal, and inactivating Glce gene in the cell, thereby obtaining a non-human mammal cell with an inactivated Glce gene; and (b) using the cell having an inactivated Glce gene obtained in step (a) to prepare and obtain a model of an animal suffering from Glce gene-inactivated obesity or a related disease. The animal model is an effective model for an animal suffering from obesity or a related disease, which may be used for researching diseases such as obesity, hyperlipidemia, hypertension, and diabetes, and may also be used for screening and testing experiments of specific drugs.