专利检索 ap:("SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES" OR "SUZHOU SUPLEAD LIFE SCIENCES CO., LTD.") AND inv:"Yaxi YANG" 第 1 页

1.

发明申请
TRIAZOLOPYRIMIDINE, TRIAZOLOPYRIDINE COMPOUNDS, AND THE COMPOSITION THEREOF FOR TREATING PRC2-MEDIATED DISEASES 审中-公开

公开(公告)号：US20200261459A1

公开(公告)日：2020-08-20

申请号：US16651510

申请日：2018-08-29

申请人： SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES , SUZHOU SUPLEAD LIFE SCIENCES CO., LTD.

发明人： Bing ZHOU , Cheng LUO , Yaxi YANG , Yuanyuan ZHANG , Daohai DU , Hualiang JIANG , Gang QIAO , Xinjun WANG

IPC分类号： A61K31/519 , C07D487/04

摘要： The present invention provides a compound represented by formula I, pharmaceutically acceptable salts, enantiomers, diastereomers or racemates thereof, the preparation method thereof, the pharmaceutical composition comprising the same, and the use thereof in the preparation of a medicament for treating a disease or condition mediated by EED and/or PRC2. The compound of the present invention can be used treating PRC2-mediated diseases or conditions.

2.

发明公开
HETEROCYCLIC COMPOUND FOR INHIBITING SHP2 ACTIVITY, PREPARATION METHOD THEREFOR AND USE THEREOF 审中-公开

公开(公告)号：US20240270753A1

公开(公告)日：2024-08-15

申请号：US18560605

申请日：2022-03-30

申请人： SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

发明人： Bing ZHOU , Jia LI , Yubo ZHOU , Xiangbo YANG , Bo FENG , Yaxi YANG , Xiaobei HU

IPC分类号： C07D491/107 , A61K31/497 , A61K31/5025 , C07D519/00

CPC分类号： C07D491/107 , A61K31/497 , A61K31/5025 , C07D519/00

摘要： The present invention relates to a heterocyclic compound for inhibiting SHP2 activity that is represented by formula I, a preparation method therefor and use thereof. The compound of the present invention is effective in treating a disease or disorder or condition mediated by SHP2.

3.

发明申请
HETEROCYCLIC AMIDE FOR INHIBITING RIP1 KINASE AND USES THEREOF 有权

公开(公告)号：US20210371430A1

公开(公告)日：2021-12-02

申请号：US17289642

申请日：2019-10-08

申请人： SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

发明人： Bing ZHOU , Wei TANG , Xiangbo YANG , Huimin LU , Mengying GAO , Yaxi YANG , Huijin FENG

IPC分类号： C07D513/04 , A61P37/06 , C07D413/14 , C07D413/12 , C07D487/04 , C07D401/14 , C07D401/12 , C07D417/14 , C07D417/12

摘要： The present invention relates to a heterocyclic amide inhibiting RIP1 kinase and the use thereof, and specifically, to a compound of formula I, its pharmaceutically acceptable salts, stereoisomers, enantiomers, diastereomers, atropisomers, optical isomers, racemates, polymorphs, solvates or isotopically labeled compounds, a pharmaceutical composition comprising the compound, and the pharmaceutical use thereof. The compound is particularly effective for treatment of diseases or disorders mediated by RIP1 kinase.