公开(公告)号：US20230383268A1

公开(公告)日：2023-11-30

申请号：US18248865

申请日：2021-10-12

申请人： SHANGHAI JUNCELL THERAPEUTICS CO., LTD.

发明人： Huajun JIN ,  Fuhui XU ,  Chen HUANG ,  Xingming MA ,  Tianyi LIU ,  Xiaochun GUO

IPC分类号： C12N9/12 ,  C12N15/85 ,  C12N15/113 ,  C12N5/0783 ,  A61K48/00

CPC分类号： C12N9/1241 ,  C12N15/85 ,  C12N15/113 ,  C12N5/0636 ,  A61K48/00 ,  C12N2510/00 ,  C12N2800/90 ,  C12N2830/50

摘要： Provided is a nucleic acid construct, including the following elements: a transposon 3′ terminal repeat, first poly A sequence, an insulator sequence having a transcription termination function, a transposon 5′ terminal repeat, a transposase coding sequence, and a promoter that controls the expression of the transposase. Also provided are a host cell or pharmaceutical composition including said nucleic acid construct, and a use thereof.