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1.
公开(公告)号:US20210369695A1
公开(公告)日:2021-12-02
申请号:US17043442
申请日:2018-11-27
发明人: Liang Chang DONG , Shizhong ZHANG , Yan JIAO , Danyong ZHANG , Wenfang ZHAO , Jingmin SHI
摘要: Disclosed is a pharmaceutical composition containing dabigatran etexilate and a preparation method thereof. The pharmaceutical composition comprises a pharmaceutically active ingredient, dabigatran etexilate and/or dabigatran etexilate mesylate, and an polymer of polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer. The mass ratio of the two is 1:0.23 to 1:3. The pharmaceutical composition not only increases the bioavailability of the pharmaceutically active ingredient, but also reduces absorption variability, and provides a more stable concentration of dabigatran in plasma, thereby reducing adverse side effects.
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公开(公告)号:US20220110832A1
公开(公告)日:2022-04-14
申请号:US17420618
申请日:2020-01-22
发明人: Liang Chang DONG , Yang LEI , Gang WU , Yan JIAO , Jingmin SHI
IPC分类号: A61J7/00 , A61K31/4439 , A61K31/197 , A61K31/47 , A61K31/43 , A61K31/7048 , A61K31/167 , A61K31/4748 , A61K31/4402 , A61K31/137 , A61K31/138
摘要: Disclosed is an oral drug delivery device, comprising a tubular member, a drug holding part, a device cap and a turbulence-creating means. The tubular member has openings at both ends and an inner cavity; the opening at one end is a first opening and the opening at the other end is a second opening; the inner cavity communicates the first opening and the second opening. The turbulence-creating means comprises a step structure or a fold structure, and is disposed in the inner cavity and positioned between the second opening and the drug holding part. By using the oral drug delivery device of the present invention, turbulence can be generated during a normal sipping process, thereby providing ample mixing of drug-containing granules or multi-particulates with drinkable liquids. Moreover, the device is telescopic, which reduces the size and is convenient to carry.
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