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公开(公告)号:US20230242486A1
公开(公告)日:2023-08-03
申请号:US18007840
申请日:2021-05-28
发明人: Jianqi LI , Yangli QI , Xiaowen CHEN , Junwei XU , Ruixiang YUAN , Qiang PU
IPC分类号: C07D213/74 , C07D213/87 , C07D401/04 , C07D405/14 , C07D405/12 , C07D405/04 , C07D409/04 , C07D409/14
CPC分类号: C07D213/74 , C07D213/87 , C07D401/04 , C07D405/14 , C07D405/12 , C07D405/04 , C07D409/04 , C07D409/14
摘要: Disclosed in the present invention are a pyridinyl morpholine compound, a preparation method therefor, and an application thereof. The present invention provides a pyridinyl morpholine compound as represented by formula I, a pharmaceutically acceptable salt thereof or a hydrate of the pharmaceutically acceptable salt thereof. The compound can be used as an antagonist for one or more of D2, D3 or 5-HT2A, and is used for preparing a drug for treating schizophrenia.
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公开(公告)号:US20230159463A1
公开(公告)日:2023-05-25
申请号:US17919190
申请日:2021-04-14
发明人: Jianqi LI , Zheng GUO , Qingwei ZHANG , Qiang PU , Zixue ZHANG , Minru JIAO
IPC分类号: C07D225/06 , C07D267/14 , C07D281/10
CPC分类号: C07D225/06 , C07D267/14 , C07D281/10
摘要: Disclosed are a benzonitric heterocyclic compound, a preparation method therefor and the use thereof. Provided in the present invention is a benzonitric heterocyclic compound represented by formula I, or a pharmaceutically acceptable salt thereof, which can be used as a histone deacetylase inhibitor, has a selective inhibitory effect on HDAC6, and has characteristics such as a high efficiency, low toxicity and ideal pharmacokinetic properties.
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