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公开(公告)号：US20220251179A1
公开(公告)日：2022-08-11
申请号：US17614288
申请日：2019-05-28
Applicant: SHANGHAITECH UNIVERSITY
Inventor： Fabio MAMMANO , Guang YANG , Francesco ZONTA
Abstract: The present technology relates generally to compositions and methods of preventing or treating diseases associated with mutant Cx26, Cx32, and/or Cx30 hemichannels. The present technology also relates to administering the anti-Cx26 hemichannel antibodies in effective amounts to treat a subject suffering from, or predisposed to, ectodermal dysplasia 2, Clouston type (OMIM No. 129500), Keratitis-ichthyosis-deafness syndrome (KIDS; OMIM No. 148210), and/or type X Charcot-Marie-Tooth neuropathy (CMTXl; OMIM No. 302800).
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