公开(公告)号：US20230287107A1

公开(公告)日：2023-09-14

申请号：US17628869

申请日：2019-07-23

Applicant: ShanghaiTech University

Inventor： Guang YANG ,  Min QIANG

IPC: C07K16/28 ,  A61P9/10

CPC classification number: C07K16/28 ,  A61P9/10 ,  C07K2317/565 ,  C07K2317/52

Abstract: The present technology relates generally to compositions and methods of preventing or treating ischemic stroke. The present technology also relates to administering the anti-ASIC1a antibodies in effective amounts to treat a subject suffering from, or predisposed to, ischemic stroke.

公开(公告)号：US20220275097A1

公开(公告)日：2022-09-01

申请号：US17623792

申请日：2019-07-02

Applicant: SHANGHAITECH UNIVERSITY

Inventor： Guang YANG ,  Pingdong TAO

IPC: C07K16/28 ,  A61P3/04

Abstract: The present technology relates generally to compositions and methods of preventing or treating diseases associated with mutantleptin receptors, leptin deficiency or leptin dysfunction. The present technology also relates to administering the anti-leptin receptor antibodies in effective amounts to treat a subject suffering from, or predisposed to, a disease associated with mutant leptin receptors, obesity, leptin deficiency, leptin resistance, and/or hypoleptinemia.

公开(公告)号：US20230174642A1

公开(公告)日：2023-06-08

申请号：US17616492

申请日：2019-06-04

Applicant: SHANGHAITECH UNIVERSITY

Inventor： Guang YANG ,  Min QIANG

IPC: C07K16/28 ,  G01N33/68 ,  A61P25/00

CPC classification number: C07K16/28 ,  G01N33/6872 ,  A61P25/00 ,  A61K2039/505

Abstract: Provided are immunoglobulin-related compositions (e.g., antibodies or antigen binding fragments thereof) that specifically bind acid-sensing ion channel 1a (ASIC1a) protein and uses of the same. Also provided is a method of administering an effective amount of the anti-ASIC1a antibodies to treat a subject suffering from, or predisposed to, acidosis, or to treat a subject suffering from a disease caused by or related to altered ASIC1a activity and/or signaling, including ischemic stroke and related conditions.

公开(公告)号：US20220251179A1

公开(公告)日：2022-08-11

申请号：US17614288

申请日：2019-05-28

Applicant: SHANGHAITECH UNIVERSITY

Inventor： Fabio MAMMANO ,  Guang YANG ,  Francesco ZONTA

IPC: C07K16/18 ,  A61P17/00

Abstract: The present technology relates generally to compositions and methods of preventing or treating diseases associated with mutant Cx26, Cx32, and/or Cx30 hemichannels. The present technology also relates to administering the anti-Cx26 hemichannel antibodies in effective amounts to treat a subject suffering from, or predisposed to, ectodermal dysplasia 2, Clouston type (OMIM No. 129500), Keratitis-ichthyosis-deafness syndrome (KIDS; OMIM No. 148210), and/or type X Charcot-Marie-Tooth neuropathy (CMTXl; OMIM No. 302800).