公开(公告)号：US20240124456A1

公开(公告)日：2024-04-18

申请号：US18274889

申请日：2022-01-29

申请人： SHANGHAITECH UNIVERSITY ,  CENTER FOR EXCELLENCE IN MOLECULAR CELL SCIENCE, CHINESE ACADEMY OF SCIENCES

发明人： Jianjun CHENG ,  Sheng WANG ,  Huan WANG ,  Luyu FAN ,  Zhangcheng CHEN ,  Jing YU ,  Jianzhong QI ,  Fen NIE

IPC分类号： C07D471/14 ,  A61P25/18 ,  A61P25/24 ,  C07D519/00

CPC分类号： C07D471/14 ,  A61P25/18 ,  A61P25/24 ,  C07D519/00 ,  C07B2200/13

摘要： An aza-ergoline derivative and a preparation method therefor and an application thereof. The derivative has a structure as shown in formula (I). The aza-ergoline derivative has good affinity, agonistic activity or selectivity to a dopamine D2 receptor.

公开(公告)号：US20240076279A1

公开(公告)日：2024-03-07

申请号：US18271523

申请日：2021-12-17

申请人： XUZHOU MEDICAL UNIVERSITY ,  SHANGHAITECH UNIVERSITY

发明人： Dong GUO ,  Xudong CAO ,  Wenzhong YAN ,  Jianjun CHENG ,  Ying SUN ,  Limin SU ,  Ying REN ,  Ruoqi WANG ,  Haoran ZHANG ,  Haoxing YUAN

IPC分类号： C07D401/12 ,  A61P13/12 ,  C07D223/16

CPC分类号： C07D401/12 ,  A61P13/12 ,  C07D223/16

摘要： The present application relates to a novel benzoazepine compound, comprising a pharmaceutically acceptable salt thereof. The present application also provides a pharmaceutical composition comprising the compound and a pharmaceutically acceptable salt thereof. The present application relates to use of the compound and the composition in the prevention or treatment of diseases related to arginine vasopressin V1a receptor, arginine vasopressin V1b receptor, arginine vasopressin V2 receptor, sympathetic nervous system or renin-angiotensin-aldosterone system. The present application also provides a method for preventing and/or treating arginine vasopressin-related diseases.