专利检索 ap:("SHANXI MEDICAL UNIVERSITY") AND inv:"Yi ZHANG" 第 1 页

1.

发明公开
ANISOMYCIN DERIVATIVE AND USE OF ANISOMYCIN AND DERIVATIVE THEREOF AS GLP-1R AGONIST 审中-公开

公开(公告)号：US20230365498A1

公开(公告)日：2023-11-16

申请号：US18357985

申请日：2023-07-24

申请人： SHANXI MEDICAL UNIVERSITY

发明人： Yi ZHANG , Huan XUE , Min ZHANG , ZhiHong LU , Linping ZHI , Zhitong WEN , Lijuan CUI , Tao BAI , Yunfeng LIU

IPC分类号： C07D207/46 , A61P3/10

CPC分类号： C07D207/46 , A61P3/10

摘要： The present invention relates to an anisomycin derivative represented by general formula (I) or pharmaceutically acceptable salts, solvates and stereoisomers thereof. According to the present invention, it is found that anisomycin and derivatives thereof have the effect of promoting insulin secretion under high blood sugar concentrations, and can treat diabetes and prevent the occurrence of hypoglycemia. It is found, by studying its mechanism of action, that the anisomycin derivative is highly related to GLP-1R, indicating that the anisomycin derivative is a small molecule GLP-1R agonist, which can effectively treat a variety of GLP-1R-mediated diseases including obesity and diabetes, and has good commercial application prospects and scientific research value.