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1.发明公开公开(公告)号：US20240226329A1
公开(公告)日：2024-07-11
申请号：US18022051
申请日：2020-08-20
Inventor： Chenli Liu , Yuxuan Dong , Xuan Guo , Qian Chen , Yong Hu , Liangxia Ai , Hao Zhang
CPC classification number: A61K48/0058 , A61K35/74 , A61K38/204 , A61K38/2066 , A61K45/06
Abstract: A bacterial targeting vector and use thereof in tumor treatment, in particular, a bacterial targeting vector carrying a cytokine such as interleukin 6 and interleukin 10 or carrying a polynucleotide such as mRNA of the cytokine and use thereof in tumor treatment. An attenuated chassis bacterium capable of targeting solid tumors can be used as a delivery carrier of a tumor therapy molecule, and achieve expression and controllable release of a human/murine cytokine, thereby achieving anti-tumor effects.
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