公开(公告)号：US20240041945A1

公开(公告)日：2024-02-08

申请号：US18265400

申请日：2020-11-05

申请人： SHENZHEN INSTITUTES OF ADVANCED TECHNOLOGY CHINESE ACADEMY OF SCIENCES

发明人： Chenli Liu ,  Zuowei Wang ,  Fangqian Sheng ,  Zhengyang Zeng ,  Weiqi Lu ,  Xuan Guo

IPC分类号： A61K35/74 ,  A61K45/06 ,  C12N1/20 ,  A61P35/00 ,  C12N1/38

CPC分类号： A61K35/74 ,  A61K45/06 ,  C12N1/205 ,  A61P35/00 ,  C12N1/38 ,  C12R2001/42

摘要： The invention relates to a method for constructing an obligate anaerobic Salmonella strain, the obligate anaerobic Salmonella strain constructed by using said method, and the use thereof in tumor therapy.

公开(公告)号：US20240226329A1

公开(公告)日：2024-07-11

申请号：US18022051

申请日：2020-08-20

申请人： SHENZHEN INSTITUTES OF ADVANCED TECHNOLOGY CHINESE ACADEMY OF SCIENCES

发明人： Chenli Liu ,  Yuxuan Dong ,  Xuan Guo ,  Qian Chen ,  Yong Hu ,  Liangxia Ai ,  Hao Zhang

IPC分类号： A61K48/00 ,  A61K35/74 ,  A61K38/20 ,  A61K45/06

CPC分类号： A61K48/0058 ,  A61K35/74 ,  A61K38/204 ,  A61K38/2066 ,  A61K45/06

摘要： A bacterial targeting vector and use thereof in tumor treatment, in particular, a bacterial targeting vector carrying a cytokine such as interleukin 6 and interleukin 10 or carrying a polynucleotide such as mRNA of the cytokine and use thereof in tumor treatment. An attenuated chassis bacterium capable of targeting solid tumors can be used as a delivery carrier of a tumor therapy molecule, and achieve expression and controllable release of a human/murine cytokine, thereby achieving anti-tumor effects.